Synthesis and crystal structure of 2-[(2,3,5,6-tetra­fluoro­pyridin-4-yl)amino]­ethyl methacrylate

In the title compound, C(11)H(10)F(4)N(2)O(2), the conformation about the N—C—C—O bond is gauche [torsion angle = 61.84 (13)°]. In the crystal, N—H⋯O hydrogen bonds link the mol­ecules into [010] chains, which are cross-linked by C—H⋯F and C—H⋯π contacts. Hirshfeld surface analysis was conducted to...

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Detalles Bibliográficos
Autores principales: Overstreet, Shayla M. J., Genzia, Ian M., Nguyen, Alexander, Auleciems, Zachary J., Jennings, Abby R., Peloquin, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242742/
https://www.ncbi.nlm.nih.gov/pubmed/37288463
http://dx.doi.org/10.1107/S2056989023004334
Descripción
Sumario:In the title compound, C(11)H(10)F(4)N(2)O(2), the conformation about the N—C—C—O bond is gauche [torsion angle = 61.84 (13)°]. In the crystal, N—H⋯O hydrogen bonds link the mol­ecules into [010] chains, which are cross-linked by C—H⋯F and C—H⋯π contacts. Hirshfeld surface analysis was conducted to aid in the visualization of these various influences on the packing. This analysis showed that the largest contribution to the surface contacts arises from F⋯H/H⋯F inter­actions (35.6%), followed by O⋯H/H⋯O (17.8%) and H⋯H (12.7%).

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