Synthesis and Evaluation of Diguanosine Cap Analogs Modified at the C8-Position by Suzuki–Miyaura Cross-Coupling: Discovery of 7-Methylguanosine-Based Molecular Rotors

[Image: see text] Chemical modifications of the mRNA cap structure can enhance the stability, translational properties, and half-life of mRNAs, thereby altering the therapeutic properties of synthetic mRNA. However, cap structure modification is challenging because of the instability of the 5′-5′-tr...

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Detalles Bibliográficos
Autores principales: Wojtczak, Blazej A., Bednarczyk, Marcelina, Sikorski, Pawel J., Wojtczak, Anna, Surynt, Piotr, Kowalska, Joanna, Jemielity, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242767/
https://www.ncbi.nlm.nih.gov/pubmed/37209102
http://dx.doi.org/10.1021/acs.joc.3c00126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242767/
https://www.ncbi.nlm.nih.gov/pubmed/37209102
http://dx.doi.org/10.1021/acs.joc.3c00126

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