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Yunnan Baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing

Microneedle patches have been extensively employed for wound healing, while the lack of rapid hemostasis efficiency and multiple tissue-repair properties restrict their values in hemorrhagic wound applications. Herein, we propose a Yunnan Baiyao-loaded multifunctional microneedle patch, namely (BY +...

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Autores principales: Yang, Jie, Wang, Xiaocheng, Wu, Dan, Yi, Kexin, Zhao, Yuanjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242798/
https://www.ncbi.nlm.nih.gov/pubmed/37280566
http://dx.doi.org/10.1186/s12951-023-01936-w
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author Yang, Jie
Wang, Xiaocheng
Wu, Dan
Yi, Kexin
Zhao, Yuanjin
author_facet Yang, Jie
Wang, Xiaocheng
Wu, Dan
Yi, Kexin
Zhao, Yuanjin
author_sort Yang, Jie
collection PubMed
description Microneedle patches have been extensively employed for wound healing, while the lack of rapid hemostasis efficiency and multiple tissue-repair properties restrict their values in hemorrhagic wound applications. Herein, we propose a Yunnan Baiyao-loaded multifunctional microneedle patch, namely (BY + EGF)@MN, with deep tissue penetration, hemostasis efficiency and regenerative properties for hemorrhagic wound healing. The (BY + EGF)@MNs are designed with a BY-loaded Bletilla striata polysaccharide (BSP) base for rapid hemostasis and epidermal growth factor (EGF)-loaded GelMA tips for subsequent wound healing. As the BSP base can be fastly dissolved and completely release BY in 6 min to promote platelet adhesion and activate coagulation system, while the EGF can achieve a controlled and sustained release behavior in 7 days with the gradual degradation of the GelMA tips, the (BY + EGF)@MNs exhibit strong pro-coagulability and satisfactory hemostatic effect in a rat hepatic hemorrhage wound model. Based on the multifunctional characteristics, we have verified that when applied in rat cutaneous wounds, the proposed MNs can accelerate the wound healing process by enhancing neovascularization, fibroblast density, and collagen deposition. Thus, we believe that such (BY + EGF)@MNs are promising candidates for rapid hemostasis and diverse wound healing applications. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01936-w.
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spelling pubmed-102427982023-06-07 Yunnan Baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing Yang, Jie Wang, Xiaocheng Wu, Dan Yi, Kexin Zhao, Yuanjin J Nanobiotechnology Research Microneedle patches have been extensively employed for wound healing, while the lack of rapid hemostasis efficiency and multiple tissue-repair properties restrict their values in hemorrhagic wound applications. Herein, we propose a Yunnan Baiyao-loaded multifunctional microneedle patch, namely (BY + EGF)@MN, with deep tissue penetration, hemostasis efficiency and regenerative properties for hemorrhagic wound healing. The (BY + EGF)@MNs are designed with a BY-loaded Bletilla striata polysaccharide (BSP) base for rapid hemostasis and epidermal growth factor (EGF)-loaded GelMA tips for subsequent wound healing. As the BSP base can be fastly dissolved and completely release BY in 6 min to promote platelet adhesion and activate coagulation system, while the EGF can achieve a controlled and sustained release behavior in 7 days with the gradual degradation of the GelMA tips, the (BY + EGF)@MNs exhibit strong pro-coagulability and satisfactory hemostatic effect in a rat hepatic hemorrhage wound model. Based on the multifunctional characteristics, we have verified that when applied in rat cutaneous wounds, the proposed MNs can accelerate the wound healing process by enhancing neovascularization, fibroblast density, and collagen deposition. Thus, we believe that such (BY + EGF)@MNs are promising candidates for rapid hemostasis and diverse wound healing applications. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01936-w. BioMed Central 2023-06-06 /pmc/articles/PMC10242798/ /pubmed/37280566 http://dx.doi.org/10.1186/s12951-023-01936-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yang, Jie
Wang, Xiaocheng
Wu, Dan
Yi, Kexin
Zhao, Yuanjin
Yunnan Baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing
title Yunnan Baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing
title_full Yunnan Baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing
title_fullStr Yunnan Baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing
title_full_unstemmed Yunnan Baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing
title_short Yunnan Baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing
title_sort yunnan baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242798/
https://www.ncbi.nlm.nih.gov/pubmed/37280566
http://dx.doi.org/10.1186/s12951-023-01936-w
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