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Anorexia nervosa and inflammatory bowel diseases—Diagnostic and genetic associations

BACKGROUND: Anorexia nervosa (AN), a serious eating disorder, and inflammatory bowel diseases (IBD) share a number of key symptoms, for example, discomfort during eating and early satiety. Despite the symptom overlap, studies on comorbidity are limited and mostly conducted in relatively small sample...

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Autores principales: Larsen, Janne Tidselbak, Yilmaz, Zeynep, Vilhjálmsson, Bjarni Jóhann, Thornton, Laura M., Benros, Michael Eriksen, Musliner, Katherine L., Werge, Thomas, Hougaard, David M., Mortensen, Preben Bo, Bulik, Cynthia M., Petersen, Liselotte Vogdrup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242845/
https://www.ncbi.nlm.nih.gov/pubmed/37431410
http://dx.doi.org/10.1002/jcv2.12036
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author Larsen, Janne Tidselbak
Yilmaz, Zeynep
Vilhjálmsson, Bjarni Jóhann
Thornton, Laura M.
Benros, Michael Eriksen
Musliner, Katherine L.
Werge, Thomas
Hougaard, David M.
Mortensen, Preben Bo
Bulik, Cynthia M.
Petersen, Liselotte Vogdrup
author_facet Larsen, Janne Tidselbak
Yilmaz, Zeynep
Vilhjálmsson, Bjarni Jóhann
Thornton, Laura M.
Benros, Michael Eriksen
Musliner, Katherine L.
Werge, Thomas
Hougaard, David M.
Mortensen, Preben Bo
Bulik, Cynthia M.
Petersen, Liselotte Vogdrup
author_sort Larsen, Janne Tidselbak
collection PubMed
description BACKGROUND: Anorexia nervosa (AN), a serious eating disorder, and inflammatory bowel diseases (IBD) share a number of key symptoms, for example, discomfort during eating and early satiety. Despite the symptom overlap, studies on comorbidity are limited and mostly conducted in relatively small samples. This study investigates the comorbidity of diagnosed AN with IBD, and the subtypes Crohn's disease and ulcerative colitis, in a population‐based sample and explores whether genetic factors could play a role in the overlap. METHODS: The study included 1,238,813 individuals born in Denmark 1981–2005 selected from the population register (5067 diagnosed with AN and 6947 diagnosed with any IBD), including a subsample of 23,236 individuals with genetic information (4271 with AN and 176 with any IBD). By combining hospital‐based diagnoses recorded in health registers until 2013 with polygenic scores (PGS) of AN and IBD, we investigated possible associations between diagnoses of each disorder, both within individuals and families, and between PGS of one disorder and diagnosis of the other disorder. Analyses were conducted using Cox regression and logistic regression. RESULTS: We found that a prior diagnosis of AN was associated with hazard ratios of 1.44 (1.05, 1.97) for any IBD, 1.60 (1.04, 2.46) for Crohn's disease, and 1.66 (1.15, 2.39) for ulcerative colitis, whereas IBD diagnoses were not significantly associated with later AN diagnosis. No significant within‐families associations were observed. We found no associations between AN and IBD using PGS. CONCLUSIONS: AN was associated with later risk of IBD, Crohn's disease, and ulcerative colitis; however, the reverse was not observed. It is important for clinicians to be aware of this association to evaluate IBD as a differential diagnosis or an emergent condition in patients with AN.
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spelling pubmed-102428452023-07-10 Anorexia nervosa and inflammatory bowel diseases—Diagnostic and genetic associations Larsen, Janne Tidselbak Yilmaz, Zeynep Vilhjálmsson, Bjarni Jóhann Thornton, Laura M. Benros, Michael Eriksen Musliner, Katherine L. Werge, Thomas Hougaard, David M. Mortensen, Preben Bo Bulik, Cynthia M. Petersen, Liselotte Vogdrup JCPP Adv Original Articles BACKGROUND: Anorexia nervosa (AN), a serious eating disorder, and inflammatory bowel diseases (IBD) share a number of key symptoms, for example, discomfort during eating and early satiety. Despite the symptom overlap, studies on comorbidity are limited and mostly conducted in relatively small samples. This study investigates the comorbidity of diagnosed AN with IBD, and the subtypes Crohn's disease and ulcerative colitis, in a population‐based sample and explores whether genetic factors could play a role in the overlap. METHODS: The study included 1,238,813 individuals born in Denmark 1981–2005 selected from the population register (5067 diagnosed with AN and 6947 diagnosed with any IBD), including a subsample of 23,236 individuals with genetic information (4271 with AN and 176 with any IBD). By combining hospital‐based diagnoses recorded in health registers until 2013 with polygenic scores (PGS) of AN and IBD, we investigated possible associations between diagnoses of each disorder, both within individuals and families, and between PGS of one disorder and diagnosis of the other disorder. Analyses were conducted using Cox regression and logistic regression. RESULTS: We found that a prior diagnosis of AN was associated with hazard ratios of 1.44 (1.05, 1.97) for any IBD, 1.60 (1.04, 2.46) for Crohn's disease, and 1.66 (1.15, 2.39) for ulcerative colitis, whereas IBD diagnoses were not significantly associated with later AN diagnosis. No significant within‐families associations were observed. We found no associations between AN and IBD using PGS. CONCLUSIONS: AN was associated with later risk of IBD, Crohn's disease, and ulcerative colitis; however, the reverse was not observed. It is important for clinicians to be aware of this association to evaluate IBD as a differential diagnosis or an emergent condition in patients with AN. John Wiley and Sons Inc. 2021-09-27 /pmc/articles/PMC10242845/ /pubmed/37431410 http://dx.doi.org/10.1002/jcv2.12036 Text en © 2021 The Authors. JCPP Advances published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Larsen, Janne Tidselbak
Yilmaz, Zeynep
Vilhjálmsson, Bjarni Jóhann
Thornton, Laura M.
Benros, Michael Eriksen
Musliner, Katherine L.
Werge, Thomas
Hougaard, David M.
Mortensen, Preben Bo
Bulik, Cynthia M.
Petersen, Liselotte Vogdrup
Anorexia nervosa and inflammatory bowel diseases—Diagnostic and genetic associations
title Anorexia nervosa and inflammatory bowel diseases—Diagnostic and genetic associations
title_full Anorexia nervosa and inflammatory bowel diseases—Diagnostic and genetic associations
title_fullStr Anorexia nervosa and inflammatory bowel diseases—Diagnostic and genetic associations
title_full_unstemmed Anorexia nervosa and inflammatory bowel diseases—Diagnostic and genetic associations
title_short Anorexia nervosa and inflammatory bowel diseases—Diagnostic and genetic associations
title_sort anorexia nervosa and inflammatory bowel diseases—diagnostic and genetic associations
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242845/
https://www.ncbi.nlm.nih.gov/pubmed/37431410
http://dx.doi.org/10.1002/jcv2.12036
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