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Prenatal alcohol exposure and child sleep problems: A family‐based quasi‐experimental study

BACKGROUND: We examine whether associations between prenatal exposure to hazardous maternal alcohol consumption during the first trimester of pregnancy and sleep problems in young children represent a causal association. METHODS: The population‐based sample consists of 15,911 mothers with 30,395 off...

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Autores principales: Lund, Ingunn Olea, Ystrom, Eivind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242890/
https://www.ncbi.nlm.nih.gov/pubmed/37431414
http://dx.doi.org/10.1002/jcv2.12111
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author Lund, Ingunn Olea
Ystrom, Eivind
author_facet Lund, Ingunn Olea
Ystrom, Eivind
author_sort Lund, Ingunn Olea
collection PubMed
description BACKGROUND: We examine whether associations between prenatal exposure to hazardous maternal alcohol consumption during the first trimester of pregnancy and sleep problems in young children represent a causal association. METHODS: The population‐based sample consists of 15,911 mothers with 30,395 offspring from the Norwegian Mother, Father, and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN). Women self‐reported pre‐pregnancy alcohol consumption and consumption during the first trimester of pregnancy twice: at gestational weeks 17 and 30. Mothers reported their children's sleep problems, when they were 1.5 and 3 years (mean = 50; SD = 10). We tested models adjusting for (1) measured confounders, (2) unmeasured familial risk factors by sibling design, and (3) maternal hazardous drinking in the 3 months prior to pregnancy as an instrumental variable within the sibling design. RESULTS: Children of mothers with hazardous drinking during the first trimester were at increased risk of sleep problems at 1.5 (β = 1.14, 95%CI 0.04–2.25) and 3 (β = 2.86, 95%CI 1.85–3.87) years of age. These associations were reduced to close to zero and non‐significant at 1.5 (β = −0.32, 95%CI −1.91–1.26) and 3 (β = 0.06, 95%CI −1.56–1.64) years when controlling for both familial and measured environmental risk factors. CONCLUSIONS: There is a moderate association between maternal hazardous drinking during pregnancy and offspring sleep problems up to age three. This association is explained by risk factors differing between families and does not reflect a cause‐effect relationship.
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spelling pubmed-102428902023-07-10 Prenatal alcohol exposure and child sleep problems: A family‐based quasi‐experimental study Lund, Ingunn Olea Ystrom, Eivind JCPP Adv Original Articles BACKGROUND: We examine whether associations between prenatal exposure to hazardous maternal alcohol consumption during the first trimester of pregnancy and sleep problems in young children represent a causal association. METHODS: The population‐based sample consists of 15,911 mothers with 30,395 offspring from the Norwegian Mother, Father, and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN). Women self‐reported pre‐pregnancy alcohol consumption and consumption during the first trimester of pregnancy twice: at gestational weeks 17 and 30. Mothers reported their children's sleep problems, when they were 1.5 and 3 years (mean = 50; SD = 10). We tested models adjusting for (1) measured confounders, (2) unmeasured familial risk factors by sibling design, and (3) maternal hazardous drinking in the 3 months prior to pregnancy as an instrumental variable within the sibling design. RESULTS: Children of mothers with hazardous drinking during the first trimester were at increased risk of sleep problems at 1.5 (β = 1.14, 95%CI 0.04–2.25) and 3 (β = 2.86, 95%CI 1.85–3.87) years of age. These associations were reduced to close to zero and non‐significant at 1.5 (β = −0.32, 95%CI −1.91–1.26) and 3 (β = 0.06, 95%CI −1.56–1.64) years when controlling for both familial and measured environmental risk factors. CONCLUSIONS: There is a moderate association between maternal hazardous drinking during pregnancy and offspring sleep problems up to age three. This association is explained by risk factors differing between families and does not reflect a cause‐effect relationship. John Wiley and Sons Inc. 2022-11-02 /pmc/articles/PMC10242890/ /pubmed/37431414 http://dx.doi.org/10.1002/jcv2.12111 Text en © 2022 The Authors. JCPP Advances published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Lund, Ingunn Olea
Ystrom, Eivind
Prenatal alcohol exposure and child sleep problems: A family‐based quasi‐experimental study
title Prenatal alcohol exposure and child sleep problems: A family‐based quasi‐experimental study
title_full Prenatal alcohol exposure and child sleep problems: A family‐based quasi‐experimental study
title_fullStr Prenatal alcohol exposure and child sleep problems: A family‐based quasi‐experimental study
title_full_unstemmed Prenatal alcohol exposure and child sleep problems: A family‐based quasi‐experimental study
title_short Prenatal alcohol exposure and child sleep problems: A family‐based quasi‐experimental study
title_sort prenatal alcohol exposure and child sleep problems: a family‐based quasi‐experimental study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242890/
https://www.ncbi.nlm.nih.gov/pubmed/37431414
http://dx.doi.org/10.1002/jcv2.12111
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