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Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study

BACKGROUND: Maternal acetaminophen use during pregnancy is associated with increased risk of ADHD in the child. This could reflect causal influence of acetaminophen on fetal neurodevelopment or could be due to confounding factors. The aim of the current study was to examine unmeasured familial confo...

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Autores principales: Gustavson, Kristin, Ystrom, Eivind, Ask, Helga, Ask Torvik, Fartein, Hornig, Mady, Susser, Ezra, Lipkin, W. Ian, Lupattelli, Angela, Stoltenberg, Camilla, Magnus, Per, Mjaaland, Siri, Askeland, Ragna Bugge, Walle, Kjersti Mæhlum, Bresnahan, Michaeline, Nordeng, Hedvig, Reichborn‐Kjennerud, Ted
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242945/
https://www.ncbi.nlm.nih.gov/pubmed/37431475
http://dx.doi.org/10.1002/jcv2.12020
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author Gustavson, Kristin
Ystrom, Eivind
Ask, Helga
Ask Torvik, Fartein
Hornig, Mady
Susser, Ezra
Lipkin, W. Ian
Lupattelli, Angela
Stoltenberg, Camilla
Magnus, Per
Mjaaland, Siri
Askeland, Ragna Bugge
Walle, Kjersti Mæhlum
Bresnahan, Michaeline
Nordeng, Hedvig
Reichborn‐Kjennerud, Ted
author_facet Gustavson, Kristin
Ystrom, Eivind
Ask, Helga
Ask Torvik, Fartein
Hornig, Mady
Susser, Ezra
Lipkin, W. Ian
Lupattelli, Angela
Stoltenberg, Camilla
Magnus, Per
Mjaaland, Siri
Askeland, Ragna Bugge
Walle, Kjersti Mæhlum
Bresnahan, Michaeline
Nordeng, Hedvig
Reichborn‐Kjennerud, Ted
author_sort Gustavson, Kristin
collection PubMed
description BACKGROUND: Maternal acetaminophen use during pregnancy is associated with increased risk of ADHD in the child. This could reflect causal influence of acetaminophen on fetal neurodevelopment or could be due to confounding factors. The aim of the current study was to examine unmeasured familial confounding factors of this association. METHODS: We used data from 26,613 children from 12,902 families participating in the prospective Norwegian Mother, Father, and Child Cohort Study (MoBa). The MoBa was linked to the Norwegian Medical Birth Register and the Norwegian Patient Registry. Siblings discordant for prenatal acetaminophen exposure were compared regarding risk of having an ADHD diagnosis. RESULTS: Children exposed to acetaminophen up to 28 days during pregnancy did not have increased risk of receiving an ADHD diagnosis compared to unexposed children. The adjusted Hazard ratio (aHR) was 0.87 (95% C.I. = 0.70‐1.08) for exposure 1 to 7 days, and 1.13 (95% C.I. = 0.82–1.49) for 8–28 days. Long‐term exposure (29 days or more) was associated with a two‐fold increase in risk of ADHD diagnosis (aHR = 2.02, 95% C.I = 1.17–3.25). In the sibling control model, the association between long‐term acetaminophen use and ADHD in the child was aHR = 2.77 (95% C.I. = 1.48–5.05) at the between‐family level, and aHR = 1.06 (95% C.I. = 0.51–2.05) at the within‐family level. CONCLUSIONS: Both the exposed and the unexposed children of mothers with long‐term use of acetaminophen in one of the pregnancies had increased risk of receiving an ADHD diagnosis. This indicates that the observed association between long‐term acetaminophen use during pregnancy and ADHD in the child may at least partly be confounded by unobserved family factors.
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spelling pubmed-102429452023-07-10 Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study Gustavson, Kristin Ystrom, Eivind Ask, Helga Ask Torvik, Fartein Hornig, Mady Susser, Ezra Lipkin, W. Ian Lupattelli, Angela Stoltenberg, Camilla Magnus, Per Mjaaland, Siri Askeland, Ragna Bugge Walle, Kjersti Mæhlum Bresnahan, Michaeline Nordeng, Hedvig Reichborn‐Kjennerud, Ted JCPP Adv Original Article BACKGROUND: Maternal acetaminophen use during pregnancy is associated with increased risk of ADHD in the child. This could reflect causal influence of acetaminophen on fetal neurodevelopment or could be due to confounding factors. The aim of the current study was to examine unmeasured familial confounding factors of this association. METHODS: We used data from 26,613 children from 12,902 families participating in the prospective Norwegian Mother, Father, and Child Cohort Study (MoBa). The MoBa was linked to the Norwegian Medical Birth Register and the Norwegian Patient Registry. Siblings discordant for prenatal acetaminophen exposure were compared regarding risk of having an ADHD diagnosis. RESULTS: Children exposed to acetaminophen up to 28 days during pregnancy did not have increased risk of receiving an ADHD diagnosis compared to unexposed children. The adjusted Hazard ratio (aHR) was 0.87 (95% C.I. = 0.70‐1.08) for exposure 1 to 7 days, and 1.13 (95% C.I. = 0.82–1.49) for 8–28 days. Long‐term exposure (29 days or more) was associated with a two‐fold increase in risk of ADHD diagnosis (aHR = 2.02, 95% C.I = 1.17–3.25). In the sibling control model, the association between long‐term acetaminophen use and ADHD in the child was aHR = 2.77 (95% C.I. = 1.48–5.05) at the between‐family level, and aHR = 1.06 (95% C.I. = 0.51–2.05) at the within‐family level. CONCLUSIONS: Both the exposed and the unexposed children of mothers with long‐term use of acetaminophen in one of the pregnancies had increased risk of receiving an ADHD diagnosis. This indicates that the observed association between long‐term acetaminophen use during pregnancy and ADHD in the child may at least partly be confounded by unobserved family factors. John Wiley and Sons Inc. 2021-06-22 /pmc/articles/PMC10242945/ /pubmed/37431475 http://dx.doi.org/10.1002/jcv2.12020 Text en © 2021 The Authors. JCPP Advances published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Gustavson, Kristin
Ystrom, Eivind
Ask, Helga
Ask Torvik, Fartein
Hornig, Mady
Susser, Ezra
Lipkin, W. Ian
Lupattelli, Angela
Stoltenberg, Camilla
Magnus, Per
Mjaaland, Siri
Askeland, Ragna Bugge
Walle, Kjersti Mæhlum
Bresnahan, Michaeline
Nordeng, Hedvig
Reichborn‐Kjennerud, Ted
Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study
title Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study
title_full Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study
title_fullStr Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study
title_full_unstemmed Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study
title_short Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study
title_sort acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242945/
https://www.ncbi.nlm.nih.gov/pubmed/37431475
http://dx.doi.org/10.1002/jcv2.12020
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