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Trends in cognitive function before and after stroke in China
BACKGROUND: While cognitive impairment after stroke is common, cognitive trends before stroke are poorly understood, especially among the Chinese population who have a relatively high stroke burden. We aimed to model the trajectories of cognitive function before and after new-onset stroke among Chin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242976/ https://www.ncbi.nlm.nih.gov/pubmed/37280632 http://dx.doi.org/10.1186/s12916-023-02908-5 |
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author | Hua, Jianian Dong, Jianye Chen, Guo-Chong Shen, Yueping |
author_facet | Hua, Jianian Dong, Jianye Chen, Guo-Chong Shen, Yueping |
author_sort | Hua, Jianian |
collection | PubMed |
description | BACKGROUND: While cognitive impairment after stroke is common, cognitive trends before stroke are poorly understood, especially among the Chinese population who have a relatively high stroke burden. We aimed to model the trajectories of cognitive function before and after new-onset stroke among Chinese. METHODS: A total of 13,311 Chinese participants aged ≥ 45 years and without a history of stroke were assessed at baseline between June 2011 and March 2012 and in at least one cognitive test between 2013 (wave 2) and 2018 (wave 4). Cognitive function was assessed using a global cognition score, which included episodic memory, visuospatial abilities, and a 10-item Telephone Interview of Cognitive Status (TICS-10) test to reflect calculation, attention, and orientation abilities. RESULTS: During the 7-year follow-up, 610 (4.6%) participants experienced a first stroke. Both stroke and non-stroke groups showed declined cognitive function during follow-up. After adjustment for covariates, there was no significant difference in pre-stroke cognitive trajectories between stroke patients and stroke-free participants. The stroke group showed an acute decline in episodic memory (− 0.123 SD), visuospatial abilities (− 0.169 SD), and global cognition (− 0.135 SD) after stroke onset. In the years following stroke, the decline rate of the TICS-10 test was higher than the rate before stroke (− 0.045 SD/year). CONCLUSIONS: Chinese stroke patients had not experienced steeper declines in cognition before stroke compared with stroke-free individuals. Incident stroke was associated with acute declines in global cognition, episodic memory, visuospatial abilities, and accelerated declines in calculation, attention, and orientation abilities. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-023-02908-5. |
format | Online Article Text |
id | pubmed-10242976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102429762023-06-07 Trends in cognitive function before and after stroke in China Hua, Jianian Dong, Jianye Chen, Guo-Chong Shen, Yueping BMC Med Research Article BACKGROUND: While cognitive impairment after stroke is common, cognitive trends before stroke are poorly understood, especially among the Chinese population who have a relatively high stroke burden. We aimed to model the trajectories of cognitive function before and after new-onset stroke among Chinese. METHODS: A total of 13,311 Chinese participants aged ≥ 45 years and without a history of stroke were assessed at baseline between June 2011 and March 2012 and in at least one cognitive test between 2013 (wave 2) and 2018 (wave 4). Cognitive function was assessed using a global cognition score, which included episodic memory, visuospatial abilities, and a 10-item Telephone Interview of Cognitive Status (TICS-10) test to reflect calculation, attention, and orientation abilities. RESULTS: During the 7-year follow-up, 610 (4.6%) participants experienced a first stroke. Both stroke and non-stroke groups showed declined cognitive function during follow-up. After adjustment for covariates, there was no significant difference in pre-stroke cognitive trajectories between stroke patients and stroke-free participants. The stroke group showed an acute decline in episodic memory (− 0.123 SD), visuospatial abilities (− 0.169 SD), and global cognition (− 0.135 SD) after stroke onset. In the years following stroke, the decline rate of the TICS-10 test was higher than the rate before stroke (− 0.045 SD/year). CONCLUSIONS: Chinese stroke patients had not experienced steeper declines in cognition before stroke compared with stroke-free individuals. Incident stroke was associated with acute declines in global cognition, episodic memory, visuospatial abilities, and accelerated declines in calculation, attention, and orientation abilities. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-023-02908-5. BioMed Central 2023-06-06 /pmc/articles/PMC10242976/ /pubmed/37280632 http://dx.doi.org/10.1186/s12916-023-02908-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Hua, Jianian Dong, Jianye Chen, Guo-Chong Shen, Yueping Trends in cognitive function before and after stroke in China |
title | Trends in cognitive function before and after stroke in China |
title_full | Trends in cognitive function before and after stroke in China |
title_fullStr | Trends in cognitive function before and after stroke in China |
title_full_unstemmed | Trends in cognitive function before and after stroke in China |
title_short | Trends in cognitive function before and after stroke in China |
title_sort | trends in cognitive function before and after stroke in china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242976/ https://www.ncbi.nlm.nih.gov/pubmed/37280632 http://dx.doi.org/10.1186/s12916-023-02908-5 |
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