Interleukin-24-mediated antitumor effects against human glioblastoma via upregulation of P38 MAPK and endogenous TRAIL-induced apoptosis and LC3-II activation-dependent autophagy

BACKGROUND: Melanoma differentiation-associated gene 7 (Mda-7) encodes IL-24, which can induce apoptosis in cancer cells. A novel gene therapy approach to treat deadly brain tumors, recombinant mda-7 adenovirus (Ad/mda-7) efficiently kills glioma cells. In this study, we investigated the factors aff...

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Detalles Bibliográficos
Autores principales: Babazadeh, Seyedeh Maliheh, Zolfaghari, Mohammad Reza, Zargar, Mohsen, Baesi, Kazem, Hosseini, Sayed Younes, Ghaemi, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242982/
https://www.ncbi.nlm.nih.gov/pubmed/37280571
http://dx.doi.org/10.1186/s12885-023-11021-y

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