Cargando…
Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report
BACKGROUND: EAU guidelines strongly recommend kidney sparing surgery (KSS) as the primary treatment option for the low-risk UTUC patients. While there are few reports involving the KSS treated for the high-risk counterparts, especially the ureteral resection. OBJECTIVE: To evaluate the effectiveness...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243015/ https://www.ncbi.nlm.nih.gov/pubmed/37277741 http://dx.doi.org/10.1186/s12894-023-01265-y |
_version_ | 1785054340625465344 |
---|---|
author | Wei, Wei Liu, Junfeng Wang, Lingdian Duan, Xiaoyu Ding, Degang |
author_facet | Wei, Wei Liu, Junfeng Wang, Lingdian Duan, Xiaoyu Ding, Degang |
author_sort | Wei, Wei |
collection | PubMed |
description | BACKGROUND: EAU guidelines strongly recommend kidney sparing surgery (KSS) as the primary treatment option for the low-risk UTUC patients. While there are few reports involving the KSS treated for the high-risk counterparts, especially the ureteral resection. OBJECTIVE: To evaluate the effectiveness and safety of the segmental ureterectomy (SU) for the patients with high-risk ureteral carcinoma. MATERIALS AND METHODS: We included 20 patients from May 2017 to December 2021 who underwent segmental ureterectomy (SU) in Henan Provincial People’s Hospital. The overall survival (OS) and progression free survival (PFS) were evaluated. Besides, the ECOG scores and postoperative complications were also included. RESULTS: As of December 2022, the mean OS was 62.1months (95%CI:55.6-68.6months) and the mean PFS was 45.0months (95%CI:35.9-54.1months). The median OS and median PFS were not reached. The 3-year OS rate was 70% and the 3-year PFS rate was 50%. The percentage of Clavien I and II complications was 15%. CONCLUSION: For the selected patients with high-risk ureteral carcinoma, the efficacy and safety of segmental ureterectomy were satisfactory. But we still need to conduct prospective or randomized study to validate the value of SU in patients with high-risk ureteral carcinoma. |
format | Online Article Text |
id | pubmed-10243015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102430152023-06-07 Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report Wei, Wei Liu, Junfeng Wang, Lingdian Duan, Xiaoyu Ding, Degang BMC Urol Research BACKGROUND: EAU guidelines strongly recommend kidney sparing surgery (KSS) as the primary treatment option for the low-risk UTUC patients. While there are few reports involving the KSS treated for the high-risk counterparts, especially the ureteral resection. OBJECTIVE: To evaluate the effectiveness and safety of the segmental ureterectomy (SU) for the patients with high-risk ureteral carcinoma. MATERIALS AND METHODS: We included 20 patients from May 2017 to December 2021 who underwent segmental ureterectomy (SU) in Henan Provincial People’s Hospital. The overall survival (OS) and progression free survival (PFS) were evaluated. Besides, the ECOG scores and postoperative complications were also included. RESULTS: As of December 2022, the mean OS was 62.1months (95%CI:55.6-68.6months) and the mean PFS was 45.0months (95%CI:35.9-54.1months). The median OS and median PFS were not reached. The 3-year OS rate was 70% and the 3-year PFS rate was 50%. The percentage of Clavien I and II complications was 15%. CONCLUSION: For the selected patients with high-risk ureteral carcinoma, the efficacy and safety of segmental ureterectomy were satisfactory. But we still need to conduct prospective or randomized study to validate the value of SU in patients with high-risk ureteral carcinoma. BioMed Central 2023-06-05 /pmc/articles/PMC10243015/ /pubmed/37277741 http://dx.doi.org/10.1186/s12894-023-01265-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Wei, Wei Liu, Junfeng Wang, Lingdian Duan, Xiaoyu Ding, Degang Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report |
title | Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report |
title_full | Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report |
title_fullStr | Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report |
title_full_unstemmed | Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report |
title_short | Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report |
title_sort | segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243015/ https://www.ncbi.nlm.nih.gov/pubmed/37277741 http://dx.doi.org/10.1186/s12894-023-01265-y |
work_keys_str_mv | AT weiwei segmentalureterectomyforhighriskureteralcarcinomaapreliminaryreport AT liujunfeng segmentalureterectomyforhighriskureteralcarcinomaapreliminaryreport AT wanglingdian segmentalureterectomyforhighriskureteralcarcinomaapreliminaryreport AT duanxiaoyu segmentalureterectomyforhighriskureteralcarcinomaapreliminaryreport AT dingdegang segmentalureterectomyforhighriskureteralcarcinomaapreliminaryreport |