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Germline variants of uncertain significance, their frequency, and clinico-pathological features in a cohort of Sri Lankan patients with hereditary breast cancer

BACKGROUND: Next-Generation Sequencing (NGS)-based testing in cancer patients has led to increased detection of variants of uncertain significance (VUS). VUS are genetic variants whose impact on protein function is unknown. VUS pose a challenge to clinicians and patients due to uncertainty regarding...

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Detalles Bibliográficos
Autores principales:	Gunawardena, Kawmadi, Sirisena, Nirmala D., Anandagoda, Gayani, Neththikumara, Nilaksha, Dissanayake, Vajira H.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243048/ https://www.ncbi.nlm.nih.gov/pubmed/37277882 http://dx.doi.org/10.1186/s13104-023-06365-4

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