EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway

Aberrant expression of circRNAs has been proven to play a crucial role in the progression of acute myeloid leukemia (AML); however, its regulatory mechanism remains unclear. Herein, we identified a novel circRNA, Circ_0001187, which is downregulated in AML patients, and its low level contributes to...

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Detalles Bibliográficos
Autores principales: Yang, Xinyu, Han, Fengjiao, Hu, Xiang, Li, Guosheng, Wu, Hanyang, Can, Can, Wei, Yihong, Liu, Jinting, Wang, Ruiqing, Jia, Wenbo, ji, Chunyan, Ma, Daoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243067/
https://www.ncbi.nlm.nih.gov/pubmed/37280654
http://dx.doi.org/10.1186/s40364-023-00495-4

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