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Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation

BACKGROUND: Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier. Apo-Tf indicates an iron-deficient environment and stimulates iron release, while holo-Tf indicates an iron sufficient environm...

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Detalles Bibliográficos
Autores principales:	Baringer, Stephanie L., Palsa, Kondaiah, Spiegelman, Vladimir S., Simpson, Ian A., Connor, James R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243088/ https://www.ncbi.nlm.nih.gov/pubmed/37277838 http://dx.doi.org/10.1186/s12929-023-00934-2

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