Integrative analysis of functional genomic screening and clinical data identifies a protective role for spironolactone in severe COVID-19

We demonstrate that integrative analysis of CRISPR screening datasets enables network-based prioritization of prescription drugs modulating viral entry in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by developing a network-based approach called Rapid proXimity Guidance for Repurposi...

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Detalles Bibliográficos
Autores principales: Cousins, Henry C., Kline, Adrienne Sarah, Wang, Chengkun, Qu, Yuanhao, Zengel, James, Carette, Jan, Wang, Mengdi, Altman, Russ B., Luo, Yuan, Cong, Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243122/
https://www.ncbi.nlm.nih.gov/pubmed/37529368
http://dx.doi.org/10.1016/j.crmeth.2023.100503

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