Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19

T cells are present in early stages of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and play a major role in disease outcome and long-lasting immunity. Nasal administration of a fully human anti-CD3 monoclonal antibody (Foralumab) reduced lung inflammation as well as se...

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Detalles Bibliográficos
Autores principales: G. Moreira, Thais, Gauthier, Christian D., Murphy, Liam, Lanser, Toby B., Paul, Anu, Matos, Kimble T. F., Mangani, Davide, Izzy, Saef, Rezende, Rafael M., Healy, Brian C., Baecher-Allan, Clare M., Chitnis, Tanuja, Kuchroo, Vijay, Weiner, Howard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243127/
https://www.ncbi.nlm.nih.gov/pubmed/36881624
http://dx.doi.org/10.1073/pnas.2220272120

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