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Chronic motor performance following different traumatic brain injury severity—A systematic review
INTRODUCTION: Traumatic brain injury (TBI) is now known to be a chronic disease, causing ongoing neurodegeneration and linked to increased risk of neurodegenerative motor diseases, such as Parkinson's disease and amyotrophic lateral sclerosis. While the presentation of motor deficits acutely fo...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243142/ https://www.ncbi.nlm.nih.gov/pubmed/37288069 http://dx.doi.org/10.3389/fneur.2023.1180353 |
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author | Corrigan, Frances Wee, Ing Chee Collins-Praino, Lyndsey E. |
author_facet | Corrigan, Frances Wee, Ing Chee Collins-Praino, Lyndsey E. |
author_sort | Corrigan, Frances |
collection | PubMed |
description | INTRODUCTION: Traumatic brain injury (TBI) is now known to be a chronic disease, causing ongoing neurodegeneration and linked to increased risk of neurodegenerative motor diseases, such as Parkinson's disease and amyotrophic lateral sclerosis. While the presentation of motor deficits acutely following traumatic brain injury is well-documented, however, less is known about how these evolve in the long-term post-injury, or how the initial severity of injury affects these outcomes. The purpose of this review, therefore, was to examine objective assessment of chronic motor impairment across the spectrum of TBI in both preclinical and clinical models. METHODS: PubMed, Embase, Scopus, and PsycINFO databases were searched with a search strategy containing key search terms for TBI and motor function. Original research articles reporting chronic motor outcomes with a clearly defined TBI severity (mild, repeated mild, moderate, moderate–severe, and severe) in an adult population were included. RESULTS: A total of 97 studies met the inclusion criteria, incorporating 62 preclinical and 35 clinical studies. Motor domains examined included neuroscore, gait, fine-motor, balance, and locomotion for preclinical studies and neuroscore, fine-motor, posture, and gait for clinical studies. There was little consensus among the articles presented, with extensive differences both in assessment methodology of the tests and parameters reported. In general, an effect of severity was seen, with more severe injury leading to persistent motor deficits, although subtle fine motor deficits were also seen clinically following repeated injury. Only six clinical studies investigated motor outcomes beyond 10 years post-injury and two preclinical studies to 18–24 months post-injury, and, as such, the interaction between a previous TBI and aging on motor performance is yet to be comprehensively examined. CONCLUSION: Further research is required to establish standardized motor assessment procedures to fully characterize chronic motor impairment across the spectrum of TBI with comprehensive outcomes and consistent protocols. Longitudinal studies investigating the same cohort over time are also a key for understanding the interaction between TBI and aging. This is particularly critical, given the risk of neurodegenerative motor disease development following TBI. |
format | Online Article Text |
id | pubmed-10243142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102431422023-06-07 Chronic motor performance following different traumatic brain injury severity—A systematic review Corrigan, Frances Wee, Ing Chee Collins-Praino, Lyndsey E. Front Neurol Neurology INTRODUCTION: Traumatic brain injury (TBI) is now known to be a chronic disease, causing ongoing neurodegeneration and linked to increased risk of neurodegenerative motor diseases, such as Parkinson's disease and amyotrophic lateral sclerosis. While the presentation of motor deficits acutely following traumatic brain injury is well-documented, however, less is known about how these evolve in the long-term post-injury, or how the initial severity of injury affects these outcomes. The purpose of this review, therefore, was to examine objective assessment of chronic motor impairment across the spectrum of TBI in both preclinical and clinical models. METHODS: PubMed, Embase, Scopus, and PsycINFO databases were searched with a search strategy containing key search terms for TBI and motor function. Original research articles reporting chronic motor outcomes with a clearly defined TBI severity (mild, repeated mild, moderate, moderate–severe, and severe) in an adult population were included. RESULTS: A total of 97 studies met the inclusion criteria, incorporating 62 preclinical and 35 clinical studies. Motor domains examined included neuroscore, gait, fine-motor, balance, and locomotion for preclinical studies and neuroscore, fine-motor, posture, and gait for clinical studies. There was little consensus among the articles presented, with extensive differences both in assessment methodology of the tests and parameters reported. In general, an effect of severity was seen, with more severe injury leading to persistent motor deficits, although subtle fine motor deficits were also seen clinically following repeated injury. Only six clinical studies investigated motor outcomes beyond 10 years post-injury and two preclinical studies to 18–24 months post-injury, and, as such, the interaction between a previous TBI and aging on motor performance is yet to be comprehensively examined. CONCLUSION: Further research is required to establish standardized motor assessment procedures to fully characterize chronic motor impairment across the spectrum of TBI with comprehensive outcomes and consistent protocols. Longitudinal studies investigating the same cohort over time are also a key for understanding the interaction between TBI and aging. This is particularly critical, given the risk of neurodegenerative motor disease development following TBI. Frontiers Media S.A. 2023-05-11 /pmc/articles/PMC10243142/ /pubmed/37288069 http://dx.doi.org/10.3389/fneur.2023.1180353 Text en Copyright © 2023 Corrigan, Wee and Collins-Praino. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Corrigan, Frances Wee, Ing Chee Collins-Praino, Lyndsey E. Chronic motor performance following different traumatic brain injury severity—A systematic review |
title | Chronic motor performance following different traumatic brain injury severity—A systematic review |
title_full | Chronic motor performance following different traumatic brain injury severity—A systematic review |
title_fullStr | Chronic motor performance following different traumatic brain injury severity—A systematic review |
title_full_unstemmed | Chronic motor performance following different traumatic brain injury severity—A systematic review |
title_short | Chronic motor performance following different traumatic brain injury severity—A systematic review |
title_sort | chronic motor performance following different traumatic brain injury severity—a systematic review |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243142/ https://www.ncbi.nlm.nih.gov/pubmed/37288069 http://dx.doi.org/10.3389/fneur.2023.1180353 |
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