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A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor

PURPOSE: A therapeutic agent that targets both viral replication and the hyper-reactive immune response would offer a highly desirable treatment for severe acute respiratory syndrome corona virus 2 (SARS-CoV-2, coronavirus disease 2019, COVID-19) management. Emvododstat (PTC299; 4-chlorophenyl 6-chl...

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Detalles Bibliográficos
Autores principales:	Morton, Terri L., Laskin, Oscar L., Kaushik, Diksha, Lee, Lucy, Ma, Jiyuan, Bar, Cristian M., Kristensen, Allan, O’Keefe, Kylie, Golden, Lee, Klein, Matthew, Kong, Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243242/ https://www.ncbi.nlm.nih.gov/pubmed/37278823 http://dx.doi.org/10.1007/s00228-023-03513-4

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