Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments

Penile cancer is a rare malignancy, most commonly diagnosed in older men, associated with poor outcomes, dramatic decline in quality of life and sexual function. Squamous cell carcinoma is the most common histopathology of penile cancer, accounting for 95% of all cases. Localized, early-stage penile...

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Autores principales: White, Joshua, Mason, Ross, Lawen, Tarek, Spooner, Jesse, Faria, Kauy V M, Rahman, Farah, Ramasamy, Ranjith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243351/
https://www.ncbi.nlm.nih.gov/pubmed/37288454
http://dx.doi.org/10.2147/RRU.S387228
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author White, Joshua
Mason, Ross
Lawen, Tarek
Spooner, Jesse
Faria, Kauy V M
Rahman, Farah
Ramasamy, Ranjith
author_facet White, Joshua
Mason, Ross
Lawen, Tarek
Spooner, Jesse
Faria, Kauy V M
Rahman, Farah
Ramasamy, Ranjith
author_sort White, Joshua
collection PubMed
description Penile cancer is a rare malignancy, most commonly diagnosed in older men, associated with poor outcomes, dramatic decline in quality of life and sexual function. Squamous cell carcinoma is the most common histopathology of penile cancer, accounting for 95% of all cases. Localized, early-stage penile cancer can be effectively managed through penile-sparing techniques in many cases, though advanced stages of penile cancer carry a poor prognosis. Current innovative treatments are exploring the role of targeted therapy, HPV-directed therapy, immune checkpoint inhibitors and adoptive T-cell therapies in treatment and prevention of relapse of penile cancer. Clinical trials are investigating the potential of targeted therapies and immune checkpoint inhibitors in advanced penile cancer. This review examines the current management of penile cancer and highlights future directions in research and treatment.
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spelling pubmed-102433512023-06-07 Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments White, Joshua Mason, Ross Lawen, Tarek Spooner, Jesse Faria, Kauy V M Rahman, Farah Ramasamy, Ranjith Res Rep Urol Review Penile cancer is a rare malignancy, most commonly diagnosed in older men, associated with poor outcomes, dramatic decline in quality of life and sexual function. Squamous cell carcinoma is the most common histopathology of penile cancer, accounting for 95% of all cases. Localized, early-stage penile cancer can be effectively managed through penile-sparing techniques in many cases, though advanced stages of penile cancer carry a poor prognosis. Current innovative treatments are exploring the role of targeted therapy, HPV-directed therapy, immune checkpoint inhibitors and adoptive T-cell therapies in treatment and prevention of relapse of penile cancer. Clinical trials are investigating the potential of targeted therapies and immune checkpoint inhibitors in advanced penile cancer. This review examines the current management of penile cancer and highlights future directions in research and treatment. Dove 2023-06-02 /pmc/articles/PMC10243351/ /pubmed/37288454 http://dx.doi.org/10.2147/RRU.S387228 Text en © 2023 White et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
White, Joshua
Mason, Ross
Lawen, Tarek
Spooner, Jesse
Faria, Kauy V M
Rahman, Farah
Ramasamy, Ranjith
Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments
title Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments
title_full Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments
title_fullStr Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments
title_full_unstemmed Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments
title_short Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments
title_sort therapeutic approaches to penile cancer: standards of care and recent developments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243351/
https://www.ncbi.nlm.nih.gov/pubmed/37288454
http://dx.doi.org/10.2147/RRU.S387228
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