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Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy

PURPOSE: To examine whether nighttime dexmedetomidine infusion improved sleep quality in patients after laryngectomy. PATIENTS AND METHODS: Thirty-five post-laryngectomy patients admitted to the intensive care unit (ICU) were randomly assigned to a 9-h (from 2100 h on surgery day to 0600 h the morni...

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Detalles Bibliográficos
Autores principales: Huang, Jingjing, Qin, Minju, Lu, Weisha, Shen, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243355/
https://www.ncbi.nlm.nih.gov/pubmed/37287698
http://dx.doi.org/10.2147/DDDT.S413321
Descripción
Sumario:PURPOSE: To examine whether nighttime dexmedetomidine infusion improved sleep quality in patients after laryngectomy. PATIENTS AND METHODS: Thirty-five post-laryngectomy patients admitted to the intensive care unit (ICU) were randomly assigned to a 9-h (from 2100 h on surgery day to 0600 h the morning after laryngectomy) dexmedetomidine (0.3 μg/kg/h continuous infusion) or placebo group. Polysomnography results were monitored during the dexmedetomidine infusion period. The percentage of stage 2 non-rapid eye movement (stage N2) sleep was the primary outcome measure. RESULTS: Thirty-five patients (18 placebo group; 17 dexmedetomidine group) had complete polysomnogram recordings. The percentage of stage N3 sleep was significantly increased in the dexmedetomidine infusion group (from median 0% (0 to 0) in placebo group to 0% (interquartile range, 0 to 4) in dexmedetomidine group (difference, −2.32%; 95% CI, −4.19 to −0.443; P = 0.0167)). Infusion had no effect on total sleep time, stage N1 or N2 sleep percentages, or sleep efficiency. It decreased muscle tensity and snore non-rapid eye movement. Subjective sleep quality improved. Hypotension incidence increased in the dexmedetomidine group, but significant intervention was not required. CONCLUSION: Dexmedetomidine infusion improved overall patient sleep quality in the ICU after laryngectomy.