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Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy

PURPOSE: To examine whether nighttime dexmedetomidine infusion improved sleep quality in patients after laryngectomy. PATIENTS AND METHODS: Thirty-five post-laryngectomy patients admitted to the intensive care unit (ICU) were randomly assigned to a 9-h (from 2100 h on surgery day to 0600 h the morni...

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Autores principales: Huang, Jingjing, Qin, Minju, Lu, Weisha, Shen, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243355/
https://www.ncbi.nlm.nih.gov/pubmed/37287698
http://dx.doi.org/10.2147/DDDT.S413321
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author Huang, Jingjing
Qin, Minju
Lu, Weisha
Shen, Xia
author_facet Huang, Jingjing
Qin, Minju
Lu, Weisha
Shen, Xia
author_sort Huang, Jingjing
collection PubMed
description PURPOSE: To examine whether nighttime dexmedetomidine infusion improved sleep quality in patients after laryngectomy. PATIENTS AND METHODS: Thirty-five post-laryngectomy patients admitted to the intensive care unit (ICU) were randomly assigned to a 9-h (from 2100 h on surgery day to 0600 h the morning after laryngectomy) dexmedetomidine (0.3 μg/kg/h continuous infusion) or placebo group. Polysomnography results were monitored during the dexmedetomidine infusion period. The percentage of stage 2 non-rapid eye movement (stage N2) sleep was the primary outcome measure. RESULTS: Thirty-five patients (18 placebo group; 17 dexmedetomidine group) had complete polysomnogram recordings. The percentage of stage N3 sleep was significantly increased in the dexmedetomidine infusion group (from median 0% (0 to 0) in placebo group to 0% (interquartile range, 0 to 4) in dexmedetomidine group (difference, −2.32%; 95% CI, −4.19 to −0.443; P = 0.0167)). Infusion had no effect on total sleep time, stage N1 or N2 sleep percentages, or sleep efficiency. It decreased muscle tensity and snore non-rapid eye movement. Subjective sleep quality improved. Hypotension incidence increased in the dexmedetomidine group, but significant intervention was not required. CONCLUSION: Dexmedetomidine infusion improved overall patient sleep quality in the ICU after laryngectomy.
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spelling pubmed-102433552023-06-07 Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy Huang, Jingjing Qin, Minju Lu, Weisha Shen, Xia Drug Des Devel Ther Original Research PURPOSE: To examine whether nighttime dexmedetomidine infusion improved sleep quality in patients after laryngectomy. PATIENTS AND METHODS: Thirty-five post-laryngectomy patients admitted to the intensive care unit (ICU) were randomly assigned to a 9-h (from 2100 h on surgery day to 0600 h the morning after laryngectomy) dexmedetomidine (0.3 μg/kg/h continuous infusion) or placebo group. Polysomnography results were monitored during the dexmedetomidine infusion period. The percentage of stage 2 non-rapid eye movement (stage N2) sleep was the primary outcome measure. RESULTS: Thirty-five patients (18 placebo group; 17 dexmedetomidine group) had complete polysomnogram recordings. The percentage of stage N3 sleep was significantly increased in the dexmedetomidine infusion group (from median 0% (0 to 0) in placebo group to 0% (interquartile range, 0 to 4) in dexmedetomidine group (difference, −2.32%; 95% CI, −4.19 to −0.443; P = 0.0167)). Infusion had no effect on total sleep time, stage N1 or N2 sleep percentages, or sleep efficiency. It decreased muscle tensity and snore non-rapid eye movement. Subjective sleep quality improved. Hypotension incidence increased in the dexmedetomidine group, but significant intervention was not required. CONCLUSION: Dexmedetomidine infusion improved overall patient sleep quality in the ICU after laryngectomy. Dove 2023-06-02 /pmc/articles/PMC10243355/ /pubmed/37287698 http://dx.doi.org/10.2147/DDDT.S413321 Text en © 2023 Huang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Huang, Jingjing
Qin, Minju
Lu, Weisha
Shen, Xia
Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy
title Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy
title_full Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy
title_fullStr Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy
title_full_unstemmed Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy
title_short Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy
title_sort dexmedetomidine improved sleep quality in the intensive care unit after laryngectomy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243355/
https://www.ncbi.nlm.nih.gov/pubmed/37287698
http://dx.doi.org/10.2147/DDDT.S413321
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