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Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic Stress
A recent research paper published in Journal of Cell Biology by Chen and colleagues describes a novel mechanism by which the MAM (Mitochondrial-associated endoplasmic reticulum membrane) protein FUNDC1 (FUN14 domain-containing protein 1) regulates mitochondrial division through altered protein post-...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243562/ https://www.ncbi.nlm.nih.gov/pubmed/37366511 http://dx.doi.org/10.1177/25152564221092487 |
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author | Zhang, Yi Zhuang, Haixia Liu, Hao Feng, Du |
author_facet | Zhang, Yi Zhuang, Haixia Liu, Hao Feng, Du |
author_sort | Zhang, Yi |
collection | PubMed |
description | A recent research paper published in Journal of Cell Biology by Chen and colleagues describes a novel mechanism by which the MAM (Mitochondrial-associated endoplasmic reticulum membrane) protein FUNDC1 (FUN14 domain-containing protein 1) regulates mitochondrial division through altered protein post-translational modifications under hypoxic stress. The authors found that in a hypoxic environment, the endoplasmic reticulum-localized deubiquitinating enzyme USP19 accumulates at the MAM and interacts with the enriched mitochondrial outer membrane protein FUNDC1, which subsequently induces its deubiquitination and promotes the oligomerization and activity of DRP1, and mitochondria eventually divide in the presence of DRP1. This article provides new insights into the regulation of mitochondrial dynamics by FUNDC1 under hypoxic condition. |
format | Online Article Text |
id | pubmed-10243562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-102435622023-06-26 Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic Stress Zhang, Yi Zhuang, Haixia Liu, Hao Feng, Du Contact (Thousand Oaks) News and Views A recent research paper published in Journal of Cell Biology by Chen and colleagues describes a novel mechanism by which the MAM (Mitochondrial-associated endoplasmic reticulum membrane) protein FUNDC1 (FUN14 domain-containing protein 1) regulates mitochondrial division through altered protein post-translational modifications under hypoxic stress. The authors found that in a hypoxic environment, the endoplasmic reticulum-localized deubiquitinating enzyme USP19 accumulates at the MAM and interacts with the enriched mitochondrial outer membrane protein FUNDC1, which subsequently induces its deubiquitination and promotes the oligomerization and activity of DRP1, and mitochondria eventually divide in the presence of DRP1. This article provides new insights into the regulation of mitochondrial dynamics by FUNDC1 under hypoxic condition. SAGE Publications 2022-04-05 /pmc/articles/PMC10243562/ /pubmed/37366511 http://dx.doi.org/10.1177/25152564221092487 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | News and Views Zhang, Yi Zhuang, Haixia Liu, Hao Feng, Du Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic Stress |
title | Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic
Stress |
title_full | Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic
Stress |
title_fullStr | Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic
Stress |
title_full_unstemmed | Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic
Stress |
title_short | Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic
Stress |
title_sort | molecular regulations of fundc1 at er-mitochondria contacts under hypoxic
stress |
topic | News and Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243562/ https://www.ncbi.nlm.nih.gov/pubmed/37366511 http://dx.doi.org/10.1177/25152564221092487 |
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