The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins

In fungi, the endoplasmic reticulum-mitochondria encounter structure (ERMES) is present between the endoplasmic reticulon (ER) and mitochondria to promote the formation of the ER-mitochondria contact sites. Four constitutive components (Mmm1, Mdm12, Mdm34, and Mdm10) assemble to form the ERMES compl...

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Detalles Bibliográficos
Autores principales: Cheema, Javairia Y., He, Jiajia, Wei, Wenfan, Fu, Chuanhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243566/
https://www.ncbi.nlm.nih.gov/pubmed/37366373
http://dx.doi.org/10.1177/25152564211064491
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author Cheema, Javairia Y.
He, Jiajia
Wei, Wenfan
Fu, Chuanhai
author_facet Cheema, Javairia Y.
He, Jiajia
Wei, Wenfan
Fu, Chuanhai
author_sort Cheema, Javairia Y.
collection PubMed
description In fungi, the endoplasmic reticulum-mitochondria encounter structure (ERMES) is present between the endoplasmic reticulon (ER) and mitochondria to promote the formation of the ER-mitochondria contact sites. Four constitutive components (Mmm1, Mdm12, Mdm34, and Mdm10) assemble to form the ERMES complex while regulator proteins are required for regulating the organization and function of the ERMES complex. Multiple regulator proteins, including Gem1, Lam6, Tom7, and Emr1, of the ERMES complex, have been identified recently. In this review, we discuss the organization of the ERMES complex and the roles of the regulator proteins of the ERMES complex.
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spelling pubmed-102435662023-06-26 The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins Cheema, Javairia Y. He, Jiajia Wei, Wenfan Fu, Chuanhai Contact (Thousand Oaks) Review In fungi, the endoplasmic reticulum-mitochondria encounter structure (ERMES) is present between the endoplasmic reticulon (ER) and mitochondria to promote the formation of the ER-mitochondria contact sites. Four constitutive components (Mmm1, Mdm12, Mdm34, and Mdm10) assemble to form the ERMES complex while regulator proteins are required for regulating the organization and function of the ERMES complex. Multiple regulator proteins, including Gem1, Lam6, Tom7, and Emr1, of the ERMES complex, have been identified recently. In this review, we discuss the organization of the ERMES complex and the roles of the regulator proteins of the ERMES complex. SAGE Publications 2021-12-06 /pmc/articles/PMC10243566/ /pubmed/37366373 http://dx.doi.org/10.1177/25152564211064491 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Cheema, Javairia Y.
He, Jiajia
Wei, Wenfan
Fu, Chuanhai
The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins
title The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins
title_full The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins
title_fullStr The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins
title_full_unstemmed The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins
title_short The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins
title_sort endoplasmic reticulum-mitochondria encounter structure and its regulatory proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243566/
https://www.ncbi.nlm.nih.gov/pubmed/37366373
http://dx.doi.org/10.1177/25152564211064491
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