Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites

Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation o...

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Detalles Bibliográficos
Autores principales: Zhemkov, Vladimir, Liou, Jen, Bezprozvanny, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243589/
https://www.ncbi.nlm.nih.gov/pubmed/37366370
http://dx.doi.org/10.1177/25152564211026505
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author Zhemkov, Vladimir
Liou, Jen
Bezprozvanny, Ilya
author_facet Zhemkov, Vladimir
Liou, Jen
Bezprozvanny, Ilya
author_sort Zhemkov, Vladimir
collection PubMed
description Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enriched ER microdomains.
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spelling pubmed-102435892023-06-26 Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites Zhemkov, Vladimir Liou, Jen Bezprozvanny, Ilya Contact (Thousand Oaks) Opinion Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enriched ER microdomains. SAGE Publications 2021-07-11 /pmc/articles/PMC10243589/ /pubmed/37366370 http://dx.doi.org/10.1177/25152564211026505 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Opinion
Zhemkov, Vladimir
Liou, Jen
Bezprozvanny, Ilya
Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites
title Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites
title_full Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites
title_fullStr Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites
title_full_unstemmed Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites
title_short Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites
title_sort sigma 1 receptor, cholesterol and endoplasmic reticulum contact sites
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243589/
https://www.ncbi.nlm.nih.gov/pubmed/37366370
http://dx.doi.org/10.1177/25152564211026505
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