Plasmin and plasminogen prevent sepsis severity by reducing neutrophil extracellular traps and systemic inflammation

Sepsis is a lethal syndrome characterized by systemic inflammation and abnormal coagulation. Despite therapeutic advances, sepsis mortality remains substantially high. Herein, we investigated the role of the plasminogen/plasmin (Plg/Pla) system during sepsis. Plasma levels of Plg were significantly...

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Detalles Bibliográficos
Autores principales: Vago, Juliana P., Zaidan, Isabella, Perucci, Luiza O., Brito, Larissa Froede, Teixeira, Lívia C.R., Silva, Camila Meirelles Souza, Miranda, Thaís C., Melo, Eliza M., Bruno, Alexandre S., Queiroz-Junior, Celso Martins, Sugimoto, Michelle A., Tavares, Luciana P., Grossi, Laís C., Borges, Isabela N., Schneider, Ayda Henriques, Baik, Nagyung, Schneider, Ayda H., Talvani, André, Ferreira, Raphael G., Alves-Filho, José C., Nobre, Vandack, Teixeira, Mauro M., Parmer, Robert J., Miles, Lindsey A., Sousa, Lirlândia P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243804/
https://www.ncbi.nlm.nih.gov/pubmed/36917195
http://dx.doi.org/10.1172/jci.insight.166044

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