Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell– and CXCR3-dependent manner

This study aimed to enhance antitumor immune responses to pancreatic cancer via Ab-based blockade of IL-6 and cytotoxic T-lymphocyte–associated protein 4 (CTLA-4). Mice bearing s.c. or orthotopic pancreatic tumors were treated with blocking Abs to IL‑6 and/or CTLA-4. In both tumor models, dual IL-6...

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Detalles Bibliográficos
Autores principales: Ware, Michael Brandon, Phillips, Maggie, McQuinn, Christopher, Zaidi, Mohammad Y., Knochelmann, Hannah M., Greene, Emily, Robinson, Brian, Herting, Cameron J., Mace, Thomas A., Chen, Zhengjia, Zhang, Chao, Farren, Matthew R., Ruggieri, Amanda N., Bowers, Jacob S., Shakya, Reena, Farris, Alton B., Young, Gregory, Carson, William E., El-Rayes, Bassel, Paulos, Chrystal M., Lesinski, Gregory B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243806/
https://www.ncbi.nlm.nih.gov/pubmed/36881480
http://dx.doi.org/10.1172/jci.insight.155006

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