Tumor loss-of-function mutations in STK11/LKB1 induce cachexia

Cancer cachexia (CC), a wasting syndrome of muscle and adipose tissue resulting in weight loss, is observed in 50% of patients with solid tumors. Management of CC is limited by the absence of biomarkers and knowledge of molecules that drive its phenotype. To identify such molecules, we injected 54 h...

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Detalles Bibliográficos
Autores principales: Iyengar, Puneeth, Gandhi, Aakash Y., Granados, Jorge, Guo, Tong, Gupta, Arun, Yu, Jinhai, Llano, Ernesto M., Zhang, Faya, Gao, Ang, Kandathil, Asha, Williams, Dorothy, Gao, Boning, Girard, Luc, Malladi, Venkat S., Shelton, John M., Evers, Bret M., Hannan, Raquibul, Ahn, Chul, Minna, John D., Infante, Rodney E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243820/
https://www.ncbi.nlm.nih.gov/pubmed/37092555
http://dx.doi.org/10.1172/jci.insight.165419

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