Lymphopenia predicts reduced survival in canine hepatocellular carcinoma

Platelet to lymphocyte ratio (PLR) is a prognostic marker in human hepatocellular carcinoma (HCC) however, its utility in canine HCC has not been explored. The aim of the study was to determine if PLR could predict survival outcomes in 42 dogs with HCC. PLR was not a significant predictive factor (p...

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Autores principales: Suarez-Rodriguez, Jose Israel, Liu, Chin-Chi, Dehghanpir, Shannon, Johnston, Andrea N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244132/
https://www.ncbi.nlm.nih.gov/pubmed/37271504
http://dx.doi.org/10.4142/jvs.22266
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author Suarez-Rodriguez, Jose Israel
Liu, Chin-Chi
Dehghanpir, Shannon
Johnston, Andrea N.
author_facet Suarez-Rodriguez, Jose Israel
Liu, Chin-Chi
Dehghanpir, Shannon
Johnston, Andrea N.
author_sort Suarez-Rodriguez, Jose Israel
collection PubMed
description Platelet to lymphocyte ratio (PLR) is a prognostic marker in human hepatocellular carcinoma (HCC) however, its utility in canine HCC has not been explored. The aim of the study was to determine if PLR could predict survival outcomes in 42 dogs with HCC. PLR was not a significant predictive factor (p = 0.15) but lymphopenia alone was significantly correlated with a reduced probability of survival (p = 0.024). Further studies are needed to evaluate if peripheral lymphocyte count mirrors that of the tumor microenvironment in canine HCC.
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spelling pubmed-102441322023-06-08 Lymphopenia predicts reduced survival in canine hepatocellular carcinoma Suarez-Rodriguez, Jose Israel Liu, Chin-Chi Dehghanpir, Shannon Johnston, Andrea N. J Vet Sci Rapid Communication Platelet to lymphocyte ratio (PLR) is a prognostic marker in human hepatocellular carcinoma (HCC) however, its utility in canine HCC has not been explored. The aim of the study was to determine if PLR could predict survival outcomes in 42 dogs with HCC. PLR was not a significant predictive factor (p = 0.15) but lymphopenia alone was significantly correlated with a reduced probability of survival (p = 0.024). Further studies are needed to evaluate if peripheral lymphocyte count mirrors that of the tumor microenvironment in canine HCC. The Korean Society of Veterinary Science 2023-04-17 /pmc/articles/PMC10244132/ /pubmed/37271504 http://dx.doi.org/10.4142/jvs.22266 Text en © 2023 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Rapid Communication
Suarez-Rodriguez, Jose Israel
Liu, Chin-Chi
Dehghanpir, Shannon
Johnston, Andrea N.
Lymphopenia predicts reduced survival in canine hepatocellular carcinoma
title Lymphopenia predicts reduced survival in canine hepatocellular carcinoma
title_full Lymphopenia predicts reduced survival in canine hepatocellular carcinoma
title_fullStr Lymphopenia predicts reduced survival in canine hepatocellular carcinoma
title_full_unstemmed Lymphopenia predicts reduced survival in canine hepatocellular carcinoma
title_short Lymphopenia predicts reduced survival in canine hepatocellular carcinoma
title_sort lymphopenia predicts reduced survival in canine hepatocellular carcinoma
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244132/
https://www.ncbi.nlm.nih.gov/pubmed/37271504
http://dx.doi.org/10.4142/jvs.22266
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