Pharmacologic targeting of Nedd8-activating enzyme reinvigorates T-cell responses in lymphoid neoplasia

Neddylation is a sequential enzyme-based process which regulates the function of E3 Cullin-RING ligase (CRL) and thus degradation of substrate proteins. Here we show that CD8(+) T cells are a direct target for therapeutically relevant anti-lymphoma activity of pevonedistat, a Nedd8-activating enzyme...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoguang, Chen, Canping, Vuong, Dan, Rodriguez-Rodriguez, Sonia, Lam, Vi, Roleder, Carly, Wang, Jing H., Kambhampati, Swetha, Berger, Allison, Pennock, Nathan, Torka, Pallawi, Hernandez-Ilizaliturri, Francisco, Siddiqi, Tanya, Wang, Lili, Xia, Zheng, Danilov, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244170/
https://www.ncbi.nlm.nih.gov/pubmed/37031300
http://dx.doi.org/10.1038/s41375-023-01889-x

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