Causal linkage of presence of mutant NPM1 to efficacy of novel therapeutic agents against AML cells with mutant NPM1

In AML with NPM1 mutation causing cytoplasmic dislocation of NPM1, treatments with Menin inhibitor (MI) and standard AML chemotherapy yield complete remissions. However, the causal and mechanistic linkage of mtNPM1 to the efficacy of these agents has not been definitively established. Utilizing CRIS...

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Detalles Bibliográficos
Autores principales: Mill, Christopher P., Fiskus, Warren, Das, Kaberi, Davis, John A., Birdwell, Christine E., Kadia, Tapan M., DiNardo, Courtney D., Daver, Naval, Takahashi, Koichi, Sasaki, Koji, McGeehan, Gerard M., Ruan, Xinjia, Su, Xiaoping, Loghavi, Sanam, Kantarjian, Hagop, Bhalla, Kapil N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244173/
https://www.ncbi.nlm.nih.gov/pubmed/36977823
http://dx.doi.org/10.1038/s41375-023-01882-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244173/
https://www.ncbi.nlm.nih.gov/pubmed/36977823
http://dx.doi.org/10.1038/s41375-023-01882-4

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