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Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage

Despite the strong evidence linking the transactive response DNA-binding protein 43 (TDP-43) aggregation to the pathogenesis of frontotemporal lobar degeneration with TDP-43, amyotrophic lateral sclerosis and several neurodegenerative diseases, our knowledge of the sequence and structural determinan...

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Detalles Bibliográficos
Autores principales:	Kumar, Senthil T., Nazarov, Sergey, Porta, Sílvia, Maharjan, Niran, Cendrowska, Urszula, Kabani, Malek, Finamore, Francesco, Xu, Yan, Lee, Virginia M.-Y., Lashuel, Hilal A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244175/ https://www.ncbi.nlm.nih.gov/pubmed/37248338 http://dx.doi.org/10.1038/s41593-023-01341-4

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