Abnormally elevated expression of ACTA2 of circular smooth muscle leads to hyperactive contraction in aganglionic segments of HSCR

BACKGROUND: Actin Alpha 2 (ACTA2) is expressed in intestinal smooth muscle cells (iSMCs) and is associated with contractility. Hirschsprung disease (HSCR), one of the most common digested tract malformations, shows peristaltic dysfunction and spasm smooth muscles. The arrangement of the circular and...

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Detalles Bibliográficos
Autores principales: Chen, Ke, You, Jingyi, Yang, Shimin, Meng, Xinyao, Chen, Xuyong, Wu, Luyao, Yu, Xiaosi, Xiao, Jun, Feng, Jiexiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244273/
https://www.ncbi.nlm.nih.gov/pubmed/37278766
http://dx.doi.org/10.1007/s00383-023-05479-x

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