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Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover

AIMS/HYPOTHESIS: PPARGC1A encodes peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders...

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Detalles Bibliográficos
Autores principales:	Huang, Mi, Claussnitzer, Melina, Saadat, Alham, Coral, Daniel E., Kalamajski, Sebastian, Franks, Paul W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244287/ https://www.ncbi.nlm.nih.gov/pubmed/37171500 http://dx.doi.org/10.1007/s00125-023-05915-6

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