GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models

AIMS/HYPOTHESIS: Wolfram syndrome is a rare autosomal recessive disorder caused by pathogenic variants in the WFS1 gene. It is characterised by insulin-dependent diabetes mellitus, optic nerve atrophy, diabetes insipidus, hearing loss and neurodegeneration. Considering the unmet treatment need for t...

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Detalles Bibliográficos
Autores principales: Gorgogietas, Vyron, Rajaei, Bahareh, Heeyoung, Chae, Santacreu, Bruno J., Marín-Cañas, Sandra, Salpea, Paraskevi, Sawatani, Toshiaki, Musuaya, Anyishai, Arroyo, María N., Moreno-Castro, Cristina, Benabdallah, Khadija, Demarez, Celine, Toivonen, Sanna, Cosentino, Cristina, Pachera, Nathalie, Lytrivi, Maria, Cai, Ying, Carnel, Lode, Brown, Cris, Urano, Fumihiko, Marchetti, Piero, Gilon, Patrick, Eizirik, Decio L., Cnop, Miriam, Igoillo-Esteve, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244297/
https://www.ncbi.nlm.nih.gov/pubmed/36995380
http://dx.doi.org/10.1007/s00125-023-05905-8

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