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Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren’s syndrome
This single-center, retrospective study aimed to investigate the course and prognostic factors of patients with primary Sjögren syndrome-associated interstitial lung disease (pSS-ILD). We included 120 pSS patients who underwent at least two high-resolution computed tomography (HRCT) scans between 20...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244322/ https://www.ncbi.nlm.nih.gov/pubmed/37280251 http://dx.doi.org/10.1038/s41598-023-35608-4 |
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author | Lee, Kyung-Ann Nam, Bo Da Hwang, Jung Hwa Kim, Hyun-Sook |
author_facet | Lee, Kyung-Ann Nam, Bo Da Hwang, Jung Hwa Kim, Hyun-Sook |
author_sort | Lee, Kyung-Ann |
collection | PubMed |
description | This single-center, retrospective study aimed to investigate the course and prognostic factors of patients with primary Sjögren syndrome-associated interstitial lung disease (pSS-ILD). We included 120 pSS patients who underwent at least two high-resolution computed tomography (HRCT) scans between 2013 and 2021. Clinical symptoms, laboratory data, HRCT findings, and pulmonary function test results were collected. Two thoracic radiologists reviewed the HRCT findings. In patients with pSS without ILD at baseline (n = 81), no development of ILD was found on follow-up (median, 2.8 years). In patients with pSS-ILD (n = 39), total disease extent, extent of coarse reticulation, and traction bronchiectasis increased on HRCT, whereas the extent of ground glass opacity (GGO) decreased at follow-up (median, 3.2 years) (each p < 0.001). In progressive group of pSS-ILD (48.7%), the extent of coarse reticulation and coarseness score of fibrosis were increased at follow-up (p < 0.05). Usual interstitial pneumonia pattern on CT (OR, 15.237) and follow-up duration (OR, 1.403) were independent risk factors for disease progression in patients with pSS-ILD. In both progressive and non-progressive pSS-ILD, GGO decreased, whereas the extent of fibrosis increased even after treatment with glucocorticoid and/or immunosuppressants. In conclusion, progression occurred in approximately half of the pSS-ILD patients with slow gradual deterioration. Our study identified a definite group of progressive pSS-ILD who did not respond to current anti-inflammatory treatment. |
format | Online Article Text |
id | pubmed-10244322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102443222023-06-08 Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren’s syndrome Lee, Kyung-Ann Nam, Bo Da Hwang, Jung Hwa Kim, Hyun-Sook Sci Rep Article This single-center, retrospective study aimed to investigate the course and prognostic factors of patients with primary Sjögren syndrome-associated interstitial lung disease (pSS-ILD). We included 120 pSS patients who underwent at least two high-resolution computed tomography (HRCT) scans between 2013 and 2021. Clinical symptoms, laboratory data, HRCT findings, and pulmonary function test results were collected. Two thoracic radiologists reviewed the HRCT findings. In patients with pSS without ILD at baseline (n = 81), no development of ILD was found on follow-up (median, 2.8 years). In patients with pSS-ILD (n = 39), total disease extent, extent of coarse reticulation, and traction bronchiectasis increased on HRCT, whereas the extent of ground glass opacity (GGO) decreased at follow-up (median, 3.2 years) (each p < 0.001). In progressive group of pSS-ILD (48.7%), the extent of coarse reticulation and coarseness score of fibrosis were increased at follow-up (p < 0.05). Usual interstitial pneumonia pattern on CT (OR, 15.237) and follow-up duration (OR, 1.403) were independent risk factors for disease progression in patients with pSS-ILD. In both progressive and non-progressive pSS-ILD, GGO decreased, whereas the extent of fibrosis increased even after treatment with glucocorticoid and/or immunosuppressants. In conclusion, progression occurred in approximately half of the pSS-ILD patients with slow gradual deterioration. Our study identified a definite group of progressive pSS-ILD who did not respond to current anti-inflammatory treatment. Nature Publishing Group UK 2023-06-06 /pmc/articles/PMC10244322/ /pubmed/37280251 http://dx.doi.org/10.1038/s41598-023-35608-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lee, Kyung-Ann Nam, Bo Da Hwang, Jung Hwa Kim, Hyun-Sook Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren’s syndrome |
title | Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren’s syndrome |
title_full | Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren’s syndrome |
title_fullStr | Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren’s syndrome |
title_full_unstemmed | Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren’s syndrome |
title_short | Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren’s syndrome |
title_sort | clinical course and risk factors for development and progression of interstitial lung disease in primary sjögren’s syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244322/ https://www.ncbi.nlm.nih.gov/pubmed/37280251 http://dx.doi.org/10.1038/s41598-023-35608-4 |
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