The monoaminergic system is a bilaterian innovation

Monoamines like serotonin, dopamine, and adrenaline/noradrenaline (epinephrine/norepinephrine) act as neuromodulators in the nervous system. They play a role in complex behaviours, cognitive functions such as learning and memory formation, as well as fundamental homeostatic processes such as sleep a...

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Autores principales: Goulty, Matthew, Botton-Amiot, Gaelle, Rosato, Ezio, Sprecher, Simon G., Feuda, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244343/
https://www.ncbi.nlm.nih.gov/pubmed/37280201
http://dx.doi.org/10.1038/s41467-023-39030-2
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author Goulty, Matthew
Botton-Amiot, Gaelle
Rosato, Ezio
Sprecher, Simon G.
Feuda, Roberto
author_facet Goulty, Matthew
Botton-Amiot, Gaelle
Rosato, Ezio
Sprecher, Simon G.
Feuda, Roberto
author_sort Goulty, Matthew
collection PubMed
description Monoamines like serotonin, dopamine, and adrenaline/noradrenaline (epinephrine/norepinephrine) act as neuromodulators in the nervous system. They play a role in complex behaviours, cognitive functions such as learning and memory formation, as well as fundamental homeostatic processes such as sleep and feeding. However, the evolutionary origin of the genes required for monoaminergic modulation is uncertain. Using a phylogenomic approach, in this study, we show that most of the genes involved in monoamine production, modulation, and reception originated in the bilaterian stem group. This suggests that the monoaminergic system is a bilaterian novelty and that its evolution may have contributed to the Cambrian diversification.
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spelling pubmed-102443432023-06-08 The monoaminergic system is a bilaterian innovation Goulty, Matthew Botton-Amiot, Gaelle Rosato, Ezio Sprecher, Simon G. Feuda, Roberto Nat Commun Article Monoamines like serotonin, dopamine, and adrenaline/noradrenaline (epinephrine/norepinephrine) act as neuromodulators in the nervous system. They play a role in complex behaviours, cognitive functions such as learning and memory formation, as well as fundamental homeostatic processes such as sleep and feeding. However, the evolutionary origin of the genes required for monoaminergic modulation is uncertain. Using a phylogenomic approach, in this study, we show that most of the genes involved in monoamine production, modulation, and reception originated in the bilaterian stem group. This suggests that the monoaminergic system is a bilaterian novelty and that its evolution may have contributed to the Cambrian diversification. Nature Publishing Group UK 2023-06-06 /pmc/articles/PMC10244343/ /pubmed/37280201 http://dx.doi.org/10.1038/s41467-023-39030-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Goulty, Matthew
Botton-Amiot, Gaelle
Rosato, Ezio
Sprecher, Simon G.
Feuda, Roberto
The monoaminergic system is a bilaterian innovation
title The monoaminergic system is a bilaterian innovation
title_full The monoaminergic system is a bilaterian innovation
title_fullStr The monoaminergic system is a bilaterian innovation
title_full_unstemmed The monoaminergic system is a bilaterian innovation
title_short The monoaminergic system is a bilaterian innovation
title_sort monoaminergic system is a bilaterian innovation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244343/
https://www.ncbi.nlm.nih.gov/pubmed/37280201
http://dx.doi.org/10.1038/s41467-023-39030-2
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