LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 is essential for the viability of mouse embryonic stem cells (mESCs), and it governs the physical properties of these cells. LIS1 dos...

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Detalles Bibliográficos
Autores principales: Kshirsagar, Aditya, Doroshev, Svetlana Maslov, Gorelik, Anna, Olender, Tsviya, Sapir, Tamar, Tsuboi, Daisuke, Rosenhek-Goldian, Irit, Malitsky, Sergey, Itkin, Maxim, Argoetti, Amir, Mandel-Gutfreund, Yael, Cohen, Sidney R., Hanna, Jacob H., Ulitsky, Igor, Kaibuchi, Kozo, Reiner, Orly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244377/
https://www.ncbi.nlm.nih.gov/pubmed/37280197
http://dx.doi.org/10.1038/s41467-023-38797-8

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