Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors

The success of cancer immunotherapy depends in part on the strength of antigen recognition by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) and structural (monomeric pMHC-TCR off-rates) avidities of 371 CD8 T cell clones specific for neoantigens, tumor-ass...

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Detalles Bibliográficos
Autores principales: Schmidt, Julien, Chiffelle, Johanna, Perez, Marta A. S., Magnin, Morgane, Bobisse, Sara, Arnaud, Marion, Genolet, Raphael, Cesbron, Julien, Barras, David, Navarro Rodrigo, Blanca, Benedetti, Fabrizio, Michel, Alexandra, Queiroz, Lise, Baumgaertner, Petra, Guillaume, Philippe, Hebeisen, Michael, Michielin, Olivier, Nguyen-Ngoc, Tu, Huber, Florian, Irving, Melita, Tissot-Renaud, Stéphanie, Stevenson, Brian J., Rusakiewicz, Sylvie, Dangaj Laniti, Denarda, Bassani-Sternberg, Michal, Rufer, Nathalie, Gfeller, David, Kandalaft, Lana E., Speiser, Daniel E., Zoete, Vincent, Coukos, George, Harari, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244384/
https://www.ncbi.nlm.nih.gov/pubmed/37280206
http://dx.doi.org/10.1038/s41467-023-38946-z

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