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A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice

Chronic heavy alcohol use is associated with lethal arrhythmias. Whether common East Asian-specific aldehyde dehydrogenase deficiency (ALDH2*2) contributes to arrhythmogenesis caused by low level alcohol use remains unclear. Here we show 59 habitual alcohol users carrying ALDH2 rs671 have longer QT...

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Detalles Bibliográficos
Autores principales:	Lee, An-Sheng, Sung, Yen-Ling, Pan, Szu-Hua, Sung, Kuo-Tzu, Su, Cheng-Huang, Ding, Shiao-Li, Lu, Ying-Jui, Hsieh, Chin-Ling, Chen, Yun-Fang, Liu, Chuan-Chuan, Chen, Wei-Yu, Chen, Xuan-Ren, Chung, Fa-Po, Wang, Shih-Wei, Chen, Che-Hong, Mochly-Rosen, Daria, Hung, Chung-Lieh, Yeh, Hung-I, Lin, Shien-Fong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244406/ https://www.ncbi.nlm.nih.gov/pubmed/37280327 http://dx.doi.org/10.1038/s42003-023-04985-x

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