Cargando…
PIE-seq: identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing
RNA-binding proteins (RBPs) are essential for gene regulation, but it remains a challenge to identify their RNA targets across cell types. Here we present PIE-Seq to investigate Protein-RNA Interaction with dual-deaminase Editing and Sequencing by conjugating C-to-U and A-to-I base editors to RBPs....
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244410/ https://www.ncbi.nlm.nih.gov/pubmed/37280234 http://dx.doi.org/10.1038/s41467-023-39054-8 |