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Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene
Eighty percent of the estimated 600 million domestic cats in the world are free-roaming. These cats typically experience suboptimal welfare and inflict high levels of predation on wildlife. Additionally, euthanasia of healthy animals in overpopulated shelters raises ethical considerations. While sur...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244415/ https://www.ncbi.nlm.nih.gov/pubmed/37280258 http://dx.doi.org/10.1038/s41467-023-38721-0 |
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author | Vansandt, Lindsey M. Meinsohn, Marie-Charlotte Godin, Philippe Nagykery, Nicholas Sicher, Natalie Kano, Motohiro Kashiwagi, Aki Chauvin, Maeva Saatcioglu, Hatice D. Barnes, Julie L. Miller, Amy G. Thompson, Amy K. Bateman, Helen L. Donelan, Elizabeth M. González, Raquel Newsom, Jackie Gao, Guangping Donahoe, Patricia K. Wang, Dan Swanson, William F. Pépin, David |
author_facet | Vansandt, Lindsey M. Meinsohn, Marie-Charlotte Godin, Philippe Nagykery, Nicholas Sicher, Natalie Kano, Motohiro Kashiwagi, Aki Chauvin, Maeva Saatcioglu, Hatice D. Barnes, Julie L. Miller, Amy G. Thompson, Amy K. Bateman, Helen L. Donelan, Elizabeth M. González, Raquel Newsom, Jackie Gao, Guangping Donahoe, Patricia K. Wang, Dan Swanson, William F. Pépin, David |
author_sort | Vansandt, Lindsey M. |
collection | PubMed |
description | Eighty percent of the estimated 600 million domestic cats in the world are free-roaming. These cats typically experience suboptimal welfare and inflict high levels of predation on wildlife. Additionally, euthanasia of healthy animals in overpopulated shelters raises ethical considerations. While surgical sterilization is the mainstay of pet population control, there is a need for efficient, safe, and cost-effective permanent contraception alternatives. Herein, we report evidence that a single intramuscular treatment with an adeno-associated viral vector delivering an anti-Müllerian hormone transgene produces long-term contraception in the domestic cat. Treated females are followed for over two years, during which transgene expression, anti-transgene antibodies, and reproductive hormones are monitored. Mating behavior and reproductive success are measured during two mating studies. Here we show that ectopic expression of anti-Müllerian hormone does not impair sex steroids nor estrous cycling, but prevents breeding-induced ovulation, resulting in safe and durable contraception in the female domestic cat. |
format | Online Article Text |
id | pubmed-10244415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102444152023-06-08 Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene Vansandt, Lindsey M. Meinsohn, Marie-Charlotte Godin, Philippe Nagykery, Nicholas Sicher, Natalie Kano, Motohiro Kashiwagi, Aki Chauvin, Maeva Saatcioglu, Hatice D. Barnes, Julie L. Miller, Amy G. Thompson, Amy K. Bateman, Helen L. Donelan, Elizabeth M. González, Raquel Newsom, Jackie Gao, Guangping Donahoe, Patricia K. Wang, Dan Swanson, William F. Pépin, David Nat Commun Article Eighty percent of the estimated 600 million domestic cats in the world are free-roaming. These cats typically experience suboptimal welfare and inflict high levels of predation on wildlife. Additionally, euthanasia of healthy animals in overpopulated shelters raises ethical considerations. While surgical sterilization is the mainstay of pet population control, there is a need for efficient, safe, and cost-effective permanent contraception alternatives. Herein, we report evidence that a single intramuscular treatment with an adeno-associated viral vector delivering an anti-Müllerian hormone transgene produces long-term contraception in the domestic cat. Treated females are followed for over two years, during which transgene expression, anti-transgene antibodies, and reproductive hormones are monitored. Mating behavior and reproductive success are measured during two mating studies. Here we show that ectopic expression of anti-Müllerian hormone does not impair sex steroids nor estrous cycling, but prevents breeding-induced ovulation, resulting in safe and durable contraception in the female domestic cat. Nature Publishing Group UK 2023-06-06 /pmc/articles/PMC10244415/ /pubmed/37280258 http://dx.doi.org/10.1038/s41467-023-38721-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Vansandt, Lindsey M. Meinsohn, Marie-Charlotte Godin, Philippe Nagykery, Nicholas Sicher, Natalie Kano, Motohiro Kashiwagi, Aki Chauvin, Maeva Saatcioglu, Hatice D. Barnes, Julie L. Miller, Amy G. Thompson, Amy K. Bateman, Helen L. Donelan, Elizabeth M. González, Raquel Newsom, Jackie Gao, Guangping Donahoe, Patricia K. Wang, Dan Swanson, William F. Pépin, David Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene |
title | Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene |
title_full | Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene |
title_fullStr | Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene |
title_full_unstemmed | Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene |
title_short | Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene |
title_sort | durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-müllerian hormone transgene |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244415/ https://www.ncbi.nlm.nih.gov/pubmed/37280258 http://dx.doi.org/10.1038/s41467-023-38721-0 |
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