Case report: Fatal poisoning caused by additive effects of two barbiturates

A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that...

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Detalles Bibliográficos
Autores principales: Takei, Sella, Kinoshita, Hiroshi, Jamal, Mostofa, Kumihashi, Mitsuru, Yamashita, Tadayoshi, Tanaka, Etsuko, Kawahara, Sachiko, Abe, Hiroko, Tsutsui, Kunihiko, Kimura, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244534/
https://www.ncbi.nlm.nih.gov/pubmed/37292155
http://dx.doi.org/10.3389/fphar.2023.1196565
Descripción
Sumario:A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that the death was due to the additive effects of two barbiturates. As both pentobarbital and phenobarbital act on gamma-aminobutyric acid (GABA) receptors, central nervous system activity was suppressed, causing respiratory depression. Additive pharmacological effects should be considered in cases of massive ingestion of multiple drugs.

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