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Case report: Fatal poisoning caused by additive effects of two barbiturates
A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244534/ https://www.ncbi.nlm.nih.gov/pubmed/37292155 http://dx.doi.org/10.3389/fphar.2023.1196565 |
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author | Takei, Sella Kinoshita, Hiroshi Jamal, Mostofa Kumihashi, Mitsuru Yamashita, Tadayoshi Tanaka, Etsuko Kawahara, Sachiko Abe, Hiroko Tsutsui, Kunihiko Kimura, Shoji |
author_facet | Takei, Sella Kinoshita, Hiroshi Jamal, Mostofa Kumihashi, Mitsuru Yamashita, Tadayoshi Tanaka, Etsuko Kawahara, Sachiko Abe, Hiroko Tsutsui, Kunihiko Kimura, Shoji |
author_sort | Takei, Sella |
collection | PubMed |
description | A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that the death was due to the additive effects of two barbiturates. As both pentobarbital and phenobarbital act on gamma-aminobutyric acid (GABA) receptors, central nervous system activity was suppressed, causing respiratory depression. Additive pharmacological effects should be considered in cases of massive ingestion of multiple drugs. |
format | Online Article Text |
id | pubmed-10244534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102445342023-06-08 Case report: Fatal poisoning caused by additive effects of two barbiturates Takei, Sella Kinoshita, Hiroshi Jamal, Mostofa Kumihashi, Mitsuru Yamashita, Tadayoshi Tanaka, Etsuko Kawahara, Sachiko Abe, Hiroko Tsutsui, Kunihiko Kimura, Shoji Front Pharmacol Pharmacology A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that the death was due to the additive effects of two barbiturates. As both pentobarbital and phenobarbital act on gamma-aminobutyric acid (GABA) receptors, central nervous system activity was suppressed, causing respiratory depression. Additive pharmacological effects should be considered in cases of massive ingestion of multiple drugs. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10244534/ /pubmed/37292155 http://dx.doi.org/10.3389/fphar.2023.1196565 Text en Copyright © 2023 Takei, Kinoshita, Jamal, Kumihashi, Yamashita, Tanaka, Kawahara, Abe, Tsutsui and Kimura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Takei, Sella Kinoshita, Hiroshi Jamal, Mostofa Kumihashi, Mitsuru Yamashita, Tadayoshi Tanaka, Etsuko Kawahara, Sachiko Abe, Hiroko Tsutsui, Kunihiko Kimura, Shoji Case report: Fatal poisoning caused by additive effects of two barbiturates |
title | Case report: Fatal poisoning caused by additive effects of two barbiturates |
title_full | Case report: Fatal poisoning caused by additive effects of two barbiturates |
title_fullStr | Case report: Fatal poisoning caused by additive effects of two barbiturates |
title_full_unstemmed | Case report: Fatal poisoning caused by additive effects of two barbiturates |
title_short | Case report: Fatal poisoning caused by additive effects of two barbiturates |
title_sort | case report: fatal poisoning caused by additive effects of two barbiturates |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244534/ https://www.ncbi.nlm.nih.gov/pubmed/37292155 http://dx.doi.org/10.3389/fphar.2023.1196565 |
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