Case report: Fatal poisoning caused by additive effects of two barbiturates

A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that...

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Autores principales: Takei, Sella, Kinoshita, Hiroshi, Jamal, Mostofa, Kumihashi, Mitsuru, Yamashita, Tadayoshi, Tanaka, Etsuko, Kawahara, Sachiko, Abe, Hiroko, Tsutsui, Kunihiko, Kimura, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244534/
https://www.ncbi.nlm.nih.gov/pubmed/37292155
http://dx.doi.org/10.3389/fphar.2023.1196565
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author Takei, Sella
Kinoshita, Hiroshi
Jamal, Mostofa
Kumihashi, Mitsuru
Yamashita, Tadayoshi
Tanaka, Etsuko
Kawahara, Sachiko
Abe, Hiroko
Tsutsui, Kunihiko
Kimura, Shoji
author_facet Takei, Sella
Kinoshita, Hiroshi
Jamal, Mostofa
Kumihashi, Mitsuru
Yamashita, Tadayoshi
Tanaka, Etsuko
Kawahara, Sachiko
Abe, Hiroko
Tsutsui, Kunihiko
Kimura, Shoji
author_sort Takei, Sella
collection PubMed
description A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that the death was due to the additive effects of two barbiturates. As both pentobarbital and phenobarbital act on gamma-aminobutyric acid (GABA) receptors, central nervous system activity was suppressed, causing respiratory depression. Additive pharmacological effects should be considered in cases of massive ingestion of multiple drugs.
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spelling pubmed-102445342023-06-08 Case report: Fatal poisoning caused by additive effects of two barbiturates Takei, Sella Kinoshita, Hiroshi Jamal, Mostofa Kumihashi, Mitsuru Yamashita, Tadayoshi Tanaka, Etsuko Kawahara, Sachiko Abe, Hiroko Tsutsui, Kunihiko Kimura, Shoji Front Pharmacol Pharmacology A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that the death was due to the additive effects of two barbiturates. As both pentobarbital and phenobarbital act on gamma-aminobutyric acid (GABA) receptors, central nervous system activity was suppressed, causing respiratory depression. Additive pharmacological effects should be considered in cases of massive ingestion of multiple drugs. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10244534/ /pubmed/37292155 http://dx.doi.org/10.3389/fphar.2023.1196565 Text en Copyright © 2023 Takei, Kinoshita, Jamal, Kumihashi, Yamashita, Tanaka, Kawahara, Abe, Tsutsui and Kimura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Takei, Sella
Kinoshita, Hiroshi
Jamal, Mostofa
Kumihashi, Mitsuru
Yamashita, Tadayoshi
Tanaka, Etsuko
Kawahara, Sachiko
Abe, Hiroko
Tsutsui, Kunihiko
Kimura, Shoji
Case report: Fatal poisoning caused by additive effects of two barbiturates
title Case report: Fatal poisoning caused by additive effects of two barbiturates
title_full Case report: Fatal poisoning caused by additive effects of two barbiturates
title_fullStr Case report: Fatal poisoning caused by additive effects of two barbiturates
title_full_unstemmed Case report: Fatal poisoning caused by additive effects of two barbiturates
title_short Case report: Fatal poisoning caused by additive effects of two barbiturates
title_sort case report: fatal poisoning caused by additive effects of two barbiturates
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244534/
https://www.ncbi.nlm.nih.gov/pubmed/37292155
http://dx.doi.org/10.3389/fphar.2023.1196565
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