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The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma

Hepatocellular carcinoma (HCC), one of the most notorious malignancies globally, has a high fatality and poor prognosis. Though remarkable breakthroughs have been made in the therapeutic strategies recently, the overall survival of HCC remains unsatisfactory. Consequently, the therapy of HCC remains...

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Autores principales: Li, Dongming, Cao, Donghui, Cui, Yingnan, Sun, Yuanlin, Jiang, Jing, Cao, Xueyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244546/
https://www.ncbi.nlm.nih.gov/pubmed/37292151
http://dx.doi.org/10.3389/fphar.2023.1201085
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author Li, Dongming
Cao, Donghui
Cui, Yingnan
Sun, Yuanlin
Jiang, Jing
Cao, Xueyuan
author_facet Li, Dongming
Cao, Donghui
Cui, Yingnan
Sun, Yuanlin
Jiang, Jing
Cao, Xueyuan
author_sort Li, Dongming
collection PubMed
description Hepatocellular carcinoma (HCC), one of the most notorious malignancies globally, has a high fatality and poor prognosis. Though remarkable breakthroughs have been made in the therapeutic strategies recently, the overall survival of HCC remains unsatisfactory. Consequently, the therapy of HCC remains a great challenge. Epigallocatechin gallate (EGCG), a natural polyphenol extracted from the leaves of the tea bush, has been extensively investigated for its antitumor effects. In this review, we summarize the previous literature to elucidate the roles of EGCG in the chemoprophylaxis and therapy of HCC. Accumulating evidence has confirmed EGCG prevents and inhibits the hepatic tumorigenesis and progression through multiple biological mechanisms, mainly involving hepatitis virus infection, oxidative stress, proliferation, invasion, migration, angiogenesis, apoptosis, autophagy, and tumor metabolism. Furthermore, EGCG enhances the efficacy and sensitivity of chemotherapy, radiotherapy, and targeted therapy in HCC. In conclusion, preclinical studies have confirmed the potential of EGCG for chemoprevention and therapy of HCC under multifarious experimental models and conditions. Nevertheless, there is an urgent need to explore the safety and efficacy of EGCG in the clinical practice of HCC.
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spelling pubmed-102445462023-06-08 The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma Li, Dongming Cao, Donghui Cui, Yingnan Sun, Yuanlin Jiang, Jing Cao, Xueyuan Front Pharmacol Pharmacology Hepatocellular carcinoma (HCC), one of the most notorious malignancies globally, has a high fatality and poor prognosis. Though remarkable breakthroughs have been made in the therapeutic strategies recently, the overall survival of HCC remains unsatisfactory. Consequently, the therapy of HCC remains a great challenge. Epigallocatechin gallate (EGCG), a natural polyphenol extracted from the leaves of the tea bush, has been extensively investigated for its antitumor effects. In this review, we summarize the previous literature to elucidate the roles of EGCG in the chemoprophylaxis and therapy of HCC. Accumulating evidence has confirmed EGCG prevents and inhibits the hepatic tumorigenesis and progression through multiple biological mechanisms, mainly involving hepatitis virus infection, oxidative stress, proliferation, invasion, migration, angiogenesis, apoptosis, autophagy, and tumor metabolism. Furthermore, EGCG enhances the efficacy and sensitivity of chemotherapy, radiotherapy, and targeted therapy in HCC. In conclusion, preclinical studies have confirmed the potential of EGCG for chemoprevention and therapy of HCC under multifarious experimental models and conditions. Nevertheless, there is an urgent need to explore the safety and efficacy of EGCG in the clinical practice of HCC. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10244546/ /pubmed/37292151 http://dx.doi.org/10.3389/fphar.2023.1201085 Text en Copyright © 2023 Li, Cao, Cui, Sun, Jiang and Cao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Dongming
Cao, Donghui
Cui, Yingnan
Sun, Yuanlin
Jiang, Jing
Cao, Xueyuan
The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma
title The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma
title_full The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma
title_fullStr The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma
title_full_unstemmed The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma
title_short The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma
title_sort potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244546/
https://www.ncbi.nlm.nih.gov/pubmed/37292151
http://dx.doi.org/10.3389/fphar.2023.1201085
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