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Microscopic polyangiitis initially presenting with idiopathic pulmonary fibrosis: a case report

Usual interstitial pneumonia is the most common type of microscopic polyangiitis (MPA)-associated interstitial lung disease, and patients may initially present with isolated pulmonary fibrosis, which often leads to a misdiagnosis of idiopathic pulmonary fibrosis (IPF). Here, we describe a patient wh...

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Detalles Bibliográficos
Autores principales: Shao, Chi, Chen, Ruxuan, Huang, Hui, Zhao, Yang, Chen, Keqi, Xu, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244548/
https://www.ncbi.nlm.nih.gov/pubmed/37293302
http://dx.doi.org/10.3389/fmed.2023.1157922
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author Shao, Chi
Chen, Ruxuan
Huang, Hui
Zhao, Yang
Chen, Keqi
Xu, Kai
author_facet Shao, Chi
Chen, Ruxuan
Huang, Hui
Zhao, Yang
Chen, Keqi
Xu, Kai
author_sort Shao, Chi
collection PubMed
description Usual interstitial pneumonia is the most common type of microscopic polyangiitis (MPA)-associated interstitial lung disease, and patients may initially present with isolated pulmonary fibrosis, which often leads to a misdiagnosis of idiopathic pulmonary fibrosis (IPF). Here, we describe a patient who developed fever of unknown origin, microscopic hematuria and renal insufficiency, who then tested positive for antineutrophil cytoplasmic antibody (ANCA) and was diagnosed with MPA after receiving antifibrotic medication for IPF (original diagnosis) for almost 10 years. The patient's symptoms were ameliorated after administration of additional glucocorticoids and immunosuppressants.
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spelling pubmed-102445482023-06-08 Microscopic polyangiitis initially presenting with idiopathic pulmonary fibrosis: a case report Shao, Chi Chen, Ruxuan Huang, Hui Zhao, Yang Chen, Keqi Xu, Kai Front Med (Lausanne) Medicine Usual interstitial pneumonia is the most common type of microscopic polyangiitis (MPA)-associated interstitial lung disease, and patients may initially present with isolated pulmonary fibrosis, which often leads to a misdiagnosis of idiopathic pulmonary fibrosis (IPF). Here, we describe a patient who developed fever of unknown origin, microscopic hematuria and renal insufficiency, who then tested positive for antineutrophil cytoplasmic antibody (ANCA) and was diagnosed with MPA after receiving antifibrotic medication for IPF (original diagnosis) for almost 10 years. The patient's symptoms were ameliorated after administration of additional glucocorticoids and immunosuppressants. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10244548/ /pubmed/37293302 http://dx.doi.org/10.3389/fmed.2023.1157922 Text en Copyright © 2023 Shao, Chen, Huang, Zhao, Chen and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Shao, Chi
Chen, Ruxuan
Huang, Hui
Zhao, Yang
Chen, Keqi
Xu, Kai
Microscopic polyangiitis initially presenting with idiopathic pulmonary fibrosis: a case report
title Microscopic polyangiitis initially presenting with idiopathic pulmonary fibrosis: a case report
title_full Microscopic polyangiitis initially presenting with idiopathic pulmonary fibrosis: a case report
title_fullStr Microscopic polyangiitis initially presenting with idiopathic pulmonary fibrosis: a case report
title_full_unstemmed Microscopic polyangiitis initially presenting with idiopathic pulmonary fibrosis: a case report
title_short Microscopic polyangiitis initially presenting with idiopathic pulmonary fibrosis: a case report
title_sort microscopic polyangiitis initially presenting with idiopathic pulmonary fibrosis: a case report
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244548/
https://www.ncbi.nlm.nih.gov/pubmed/37293302
http://dx.doi.org/10.3389/fmed.2023.1157922
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