Missense variant interaction scanning reveals a critical role of the FERM domain for tumor suppressor protein NF2 conformation and function

NF2 (moesin–ezrin–radixin-like [MERLIN] tumor suppressor) is frequently inactivated in cancer, where its NF2 tumor suppressor functionality is tightly coupled to protein conformation. How NF2 conformation is regulated and how NF2 conformation influences tumor suppressor activity is a largely open qu...

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Detalles Bibliográficos
Autores principales: Moesslacher, Christina S, Auernig, Elisabeth, Woodsmith, Jonathan, Feichtner, Andreas, Jany-Luig, Evelyne, Jehle, Stefanie, Worseck, Josephine M, Heine, Christian L, Stefan, Eduard, Stelzl, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244618/
https://www.ncbi.nlm.nih.gov/pubmed/37280085
http://dx.doi.org/10.26508/lsa.202302043

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