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Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon

BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus known to cause two major diseases: adult T-cell leukemia/lymphoma and a progressive neuromyelopathy—tropical spastic paraparesis. Many viruses may be involved in the pathogenesis of thyroiditis; however, few studies have focused...

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Autores principales: Dugardin, Julia, Demar, Magalie, Hafsi, Nezha, Amroun, Hakim, Aurelus, Jean-Markens, Drak Alsibai, Kinan, Ntoutoum, André, Santa, Florin, Nacher, Mathieu, Sabbah, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244722/
https://www.ncbi.nlm.nih.gov/pubmed/37293205
http://dx.doi.org/10.3389/fcimb.2023.1164526
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author Dugardin, Julia
Demar, Magalie
Hafsi, Nezha
Amroun, Hakim
Aurelus, Jean-Markens
Drak Alsibai, Kinan
Ntoutoum, André
Santa, Florin
Nacher, Mathieu
Sabbah, Nadia
author_facet Dugardin, Julia
Demar, Magalie
Hafsi, Nezha
Amroun, Hakim
Aurelus, Jean-Markens
Drak Alsibai, Kinan
Ntoutoum, André
Santa, Florin
Nacher, Mathieu
Sabbah, Nadia
author_sort Dugardin, Julia
collection PubMed
description BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus known to cause two major diseases: adult T-cell leukemia/lymphoma and a progressive neuromyelopathy—tropical spastic paraparesis. Many viruses may be involved in the pathogenesis of thyroiditis; however, few studies have focused on the role of HTLV-1. We aimed to investigate the association between HTLV-1 and biological thyroid dysfunction. METHODS: We included 357 patients with a positive HTLV-1 serology and thyroid-stimulating hormone assay data between 2012 and 2021 in a hospital in French Guiana; we compared the prevalence of hypothyroidism and hyperthyroidism in this group with that in an HTLV-1-negative control group (722 persons) matched for sex and age. RESULTS: The prevalence of hypothyroidism and hyperthyroidism in patients with HTLV-1 infection was significantly higher than that in the control group (11% versus 3.2% and 11.3% versus 2.3%, respectively; p < 0.001). CONCLUSION: Our study shows, for the first time, the association between HTLV-1 and dysthyroidism in a large sample, suggesting that thyroid function exploration should be systematically implemented in this population as this may have an impact on therapeutic management.
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spelling pubmed-102447222023-06-08 Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon Dugardin, Julia Demar, Magalie Hafsi, Nezha Amroun, Hakim Aurelus, Jean-Markens Drak Alsibai, Kinan Ntoutoum, André Santa, Florin Nacher, Mathieu Sabbah, Nadia Front Cell Infect Microbiol Cellular and Infection Microbiology BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus known to cause two major diseases: adult T-cell leukemia/lymphoma and a progressive neuromyelopathy—tropical spastic paraparesis. Many viruses may be involved in the pathogenesis of thyroiditis; however, few studies have focused on the role of HTLV-1. We aimed to investigate the association between HTLV-1 and biological thyroid dysfunction. METHODS: We included 357 patients with a positive HTLV-1 serology and thyroid-stimulating hormone assay data between 2012 and 2021 in a hospital in French Guiana; we compared the prevalence of hypothyroidism and hyperthyroidism in this group with that in an HTLV-1-negative control group (722 persons) matched for sex and age. RESULTS: The prevalence of hypothyroidism and hyperthyroidism in patients with HTLV-1 infection was significantly higher than that in the control group (11% versus 3.2% and 11.3% versus 2.3%, respectively; p < 0.001). CONCLUSION: Our study shows, for the first time, the association between HTLV-1 and dysthyroidism in a large sample, suggesting that thyroid function exploration should be systematically implemented in this population as this may have an impact on therapeutic management. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10244722/ /pubmed/37293205 http://dx.doi.org/10.3389/fcimb.2023.1164526 Text en Copyright © 2023 Dugardin, Demar, Hafsi, Amroun, Aurelus, Drak Alsibai, Ntoutoum, Santa, Nacher and Sabbah https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Dugardin, Julia
Demar, Magalie
Hafsi, Nezha
Amroun, Hakim
Aurelus, Jean-Markens
Drak Alsibai, Kinan
Ntoutoum, André
Santa, Florin
Nacher, Mathieu
Sabbah, Nadia
Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon
title Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon
title_full Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon
title_fullStr Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon
title_full_unstemmed Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon
title_short Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon
title_sort human t-cell leukemia virus type 1 is associated with dysthyroidism in the french amazon
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244722/
https://www.ncbi.nlm.nih.gov/pubmed/37293205
http://dx.doi.org/10.3389/fcimb.2023.1164526
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