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Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery
Background: To design a vascular pedicled fascia-prosthesis compound model that can be used for ear reconstruction surgery. Methods: A vascularized tissue engineering chamber model was constructed in New Zealand rabbits, and fresh tissues were obtained after 4 weeks. The histomorphology and vascular...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244754/ https://www.ncbi.nlm.nih.gov/pubmed/37292096 http://dx.doi.org/10.3389/fbioe.2023.1126269 |
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author | Li, Guanmin Lei, Chen Shan, Xiuying Ni, Xuejun Chen, Guojie Wang, Meishui Ke, Ruonan Wang, Biao |
author_facet | Li, Guanmin Lei, Chen Shan, Xiuying Ni, Xuejun Chen, Guojie Wang, Meishui Ke, Ruonan Wang, Biao |
author_sort | Li, Guanmin |
collection | PubMed |
description | Background: To design a vascular pedicled fascia-prosthesis compound model that can be used for ear reconstruction surgery. Methods: A vascularized tissue engineering chamber model was constructed in New Zealand rabbits, and fresh tissues were obtained after 4 weeks. The histomorphology and vascularization of the newly born tissue compound were analyzed and evaluated by tissue staining and Micro-CT scanning. Results: The neoplastic fibrous tissue formed in the vascularized tissue engineering chamber with the introduction of abdominal superficial vessels, similar to normal fascia, was superior to the control group in terms of vascularization, vascular density, total vascular volume, and total vascular volume/total tissue volume. Conclusion: In vivo, introducing abdominal superficial vessels in the tissue engineering chamber prepped for ear prosthesis may form a well-vascularized pedicled fascia-prosthesis compound that can be used for ear reconstruction. |
format | Online Article Text |
id | pubmed-10244754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102447542023-06-08 Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery Li, Guanmin Lei, Chen Shan, Xiuying Ni, Xuejun Chen, Guojie Wang, Meishui Ke, Ruonan Wang, Biao Front Bioeng Biotechnol Bioengineering and Biotechnology Background: To design a vascular pedicled fascia-prosthesis compound model that can be used for ear reconstruction surgery. Methods: A vascularized tissue engineering chamber model was constructed in New Zealand rabbits, and fresh tissues were obtained after 4 weeks. The histomorphology and vascularization of the newly born tissue compound were analyzed and evaluated by tissue staining and Micro-CT scanning. Results: The neoplastic fibrous tissue formed in the vascularized tissue engineering chamber with the introduction of abdominal superficial vessels, similar to normal fascia, was superior to the control group in terms of vascularization, vascular density, total vascular volume, and total vascular volume/total tissue volume. Conclusion: In vivo, introducing abdominal superficial vessels in the tissue engineering chamber prepped for ear prosthesis may form a well-vascularized pedicled fascia-prosthesis compound that can be used for ear reconstruction. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10244754/ /pubmed/37292096 http://dx.doi.org/10.3389/fbioe.2023.1126269 Text en Copyright © 2023 Li, Lei, Shan, Ni, Chen, Wang, Ke and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Li, Guanmin Lei, Chen Shan, Xiuying Ni, Xuejun Chen, Guojie Wang, Meishui Ke, Ruonan Wang, Biao Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
title | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
title_full | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
title_fullStr | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
title_full_unstemmed | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
title_short | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
title_sort | construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244754/ https://www.ncbi.nlm.nih.gov/pubmed/37292096 http://dx.doi.org/10.3389/fbioe.2023.1126269 |
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