Cargando…

Medical cannabinoids for painful symptoms in patients with severe dementia: a randomized, double-blind cross-over placebo-controlled trial protocol

BACKGROUND: In an observational study in Geneva (Switzerland), we found that administering a standardized THC/CBD oil was feasible, safe, and beneficial in an elderly polymedicated population with severe dementia, behavioral troubles, and pain. Those findings need to be confirmed in a randomized cli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bianchi, Federica, Pautex, Sophie, Wampfler, James, Curtin, François, Daali, Youssef, Desmeules, Jules Alexandre, Broers, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pain Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244760/ https://www.ncbi.nlm.nih.gov/pubmed/37293434 http://dx.doi.org/10.3389/fpain.2023.1108832

Ejemplares similares

Cannabinoids for behavioral symptoms in severe dementia: Safety and feasibility in a long-term pilot observational study in nineteen patients
por: Pautex, Sophie, et al.
Publicado: (2022)

Patient-Related Barriers to the Prescription of Cannabinoid-Based Medicines in Palliative Care: A Qualitative Approach
por: Kalonji, Pauline, et al.
Publicado: (2022)

Physiologically‐Based Pharmacokinetic Modeling for the Prediction of CYP2D6‐Mediated Gene–Drug–Drug Interactions
por: Storelli, Flavia, et al.
Publicado: (2019)

High-dose steroids in high pain responders undergoing total knee arthroplasty: a randomised double-blind trial
por: Nielsen, Niklas I., et al.
Publicado: (2022)

Uptake/Efflux Transport of Tramadol Enantiomers and O-Desmethyl-Tramadol: Focus on P-Glycoprotein
por: Kanaan, Mouna, et al.
Publicado: (2009)

Impact of SARS‐CoV‐2 Infection (COVID‐19) on Cytochromes P450 Activity Assessed by the Geneva Cocktail
por: Lenoir, Camille, et al.
Publicado: (2021)

Cannabinoids and COVID-19
por: El Biali, Myriam, et al.
Publicado: (2020)

Interaction between Fexofenadine and CYP Phenotyping Probe Drugs in Geneva Cocktail
por: Bosilkovska, Marija, et al.
Publicado: (2019)

The 1β-Hydroxy-Deoxycholic Acid to Deoxycholic Acid Urinary Metabolic Ratio: Toward a Phenotyping of CYP3A Using an Endogenous Marker?
por: Magliocco, Gaëlle, et al.
Publicado: (2021)

Cannabinoid Receptors and Their Relationship With Chronic Pain: A Narrative Review
por: Anthony, Adarsh Thomas, et al.
Publicado: (2020)

Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokinetics
por: Lenoir, Camille, et al.
Publicado: (2021)

Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect
por: Ing Lorenzini, Kuntheavy, et al.
Publicado: (2016)

Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6‐hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots
por: Magliocco, Gaëlle, et al.
Publicado: (2022)

The Endocannabinoid System, Cannabinoids, and Pain
por: Fine, Perry G., et al.
Publicado: (2013)

Paravertebral Block with Compound Betamethasone in Laparoscopic Cholecystectomy: A Double-blind Randomized Controlled Trial
por: Li, Jinlei, et al.
Publicado: (2019)

Autologous Whole-Blood Versus Corticosteroid Local Injection in Treatment of Plantar Fasciitis: A Randomized Single Blind Placebo-Controlled Study
por: Digra, Nikhil, et al.
Publicado: (2023)

A Multi-Center, Randomized, Double-Blind Placebo-Controlled Trial of Intravenous-Ibuprofen (IV-Ibuprofen) for Treatment of Pain in Post-Operative Orthopedic Adult Patients
por: Singla, Neil, et al.
Publicado: (2010)

Reviewing Data Integrated for PBPK Model Development to Predict Metabolic Drug-Drug Interactions: Shifting Perspectives and Emerging Trends
por: Abouir, Kenza, et al.
Publicado: (2021)

Evaluation of Pupillometry for CYP2D6 Phenotyping in Children Treated with Tramadol
por: Rodieux, Frédérique, et al.
Publicado: (2023)

Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
por: Chaves, Carolina, et al.
Publicado: (2020)

Autonomic nervous system markers of music-elicited analgesia in people with fibromyalgia: A double-blind randomized pilot study
por: Lepping, Rebecca J., et al.
Publicado: (2022)

Intranasal Dexmedetomidine for Pain Management in Older Patients: A Cross-Over, Randomized, Double-Blinded, Active-Controlled Trial
por: Dieudonné Rahm, Nathalie, et al.
Publicado: (2023)

Sex Differences in a Rat Model of Peripheral Neuropathic Pain and Associated Levels of Endogenous Cannabinoid Ligands
por: Boullon, Laura, et al.
Publicado: (2021)

Characteristics of People Seeking Prescribed Cannabinoids for the Treatment of Chronic Pain: Evidence From Project Twenty 21
por: Schlag, Anne Katrin, et al.
Publicado: (2022)

Double-Blind Randomized Controlled Trial Comparing Platelet-Rich Plasma With Intra-Articular Corticosteroid Injections in Patients With Bilateral Knee Osteoarthritis
por: Pretorius, Jacques, et al.
Publicado: (2022)

Placebo, nocebo: Believing in the field of medicine
por: Meissner, Karin
Publicado: (2022)

Editorial: Pain and dementia
por: Lautenbacher, Stefan
Publicado: (2023)

Additional effect of magnesium sulfate and vitamin C in laparoscopic gynecologic surgery for postoperative pain management: a double-blind randomized controlled trial
por: Moon, Sungho, et al.
Publicado: (2020)

Pharmacokinetic Interaction Between Prasugrel and Ritonavir in Healthy Volunteers
por: Ancrenaz, Virginie, et al.
Publicado: (2013)

Cannabinoid Receptor 1 Expression in Human Dorsal Root Ganglia and CB13-Induced Bidirectional Modulation of Sensory Neuron Activity
por: Ford, Zachary K., et al.
Publicado: (2021)

Impact of Acute Inflammation on Cytochromes P450 Activity Assessed by the Geneva Cocktail
por: Lenoir, Camille, et al.
Publicado: (2021)

Editorial: Placebo Effect in Pain and Pain Treatment
por: Bernstein, Michael H., et al.
Publicado: (2022)

Can the Open Label Placebo Rationale Be Optimized?
por: Heiss, Uwe, et al.
Publicado: (2021)

Cannabinoid Effect and Safety in Spasticity Following Stroke: A Double-Blind Randomized Placebo-Controlled Study
por: Marinelli, Lucio, et al.
Publicado: (2022)

Historical evolution of the scientific investigation of the placebo analgesic effect
por: Benedetti, Fabrizio
Publicado: (2022)

High and Mighty? Cannabinoids and the microbiome in pain
por: Rea, Kieran, et al.
Publicado: (2021)

Baseline heart rate variability predicts placebo hypoalgesia in men, but not women
por: Krecké, Joy, et al.
Publicado: (2023)

CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting
por: Ing Lorenzini, Kuntheavy, et al.
Publicado: (2021)

A Phase 3, Randomized, Double-Blind Comparison of Analgesic Efficacy and Tolerability of Q8003 vs Oxycodone or Morphine for Moderate-to-Severe Postoperative Pain Following Bunionectomy Surgery
por: Richards, Patricia, et al.
Publicado: (2013)

Mental practice in isolation improves cervical joint position sense in patients with chronic neck pain: a randomized single-blind placebo trial
por: Cuenca-Martínez, Ferran, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1cumamafq0q0nihqhrrcmdmb9v