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Frequency-dependent and time-variant alterations of neural activity in post-stroke depression: A resting-state fMRI study
BACKGROUND: Post-stroke depression (PSD) is one of the most frequent psychiatric disorders after stroke. However, the underlying brain mechanism of PSD remains unclarified. Using the amplitude of low-frequency fluctuation (ALFF) approach, we aimed to investigate the abnormalities of neural activity...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244813/ https://www.ncbi.nlm.nih.gov/pubmed/37269698 http://dx.doi.org/10.1016/j.nicl.2023.103445 |
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author | Wu, Xiumei Wang, Luoyu Jiang, Haibo Fu, Yanhui Wang, Tiantian Ma, Zhenqiang Wu, Xiaoyan Wang, Yiying Fan, Fengmei Song, Yulin Lv, Yating |
author_facet | Wu, Xiumei Wang, Luoyu Jiang, Haibo Fu, Yanhui Wang, Tiantian Ma, Zhenqiang Wu, Xiaoyan Wang, Yiying Fan, Fengmei Song, Yulin Lv, Yating |
author_sort | Wu, Xiumei |
collection | PubMed |
description | BACKGROUND: Post-stroke depression (PSD) is one of the most frequent psychiatric disorders after stroke. However, the underlying brain mechanism of PSD remains unclarified. Using the amplitude of low-frequency fluctuation (ALFF) approach, we aimed to investigate the abnormalities of neural activity in PSD patients, and further explored the frequency and time properties of ALFF changes in PSD. METHODS: Resting-state fMRI data and clinical data were collected from 39 PSD patients (PSD), 82 S patients without depression (Stroke), and 74 age- and sex-matched healthy controls (HC). ALFF across three frequency bands (ALFF-Classic: 0.01–0.08 Hz; ALFF-Slow4: 0.027–0.073 Hz; ALFF-Slow5: 0.01–0.027 Hz) and dynamic ALFF (dALFF) were computed and compared among three groups. Ridge regression analyses and spearman’s correlation analyses were further applied to explore the relationship between PSD-specific alterations and depression severity in PSD. RESULTS: We found that PSD-specific alterations of ALFF were frequency-dependent and time-variant. Specially, compared to both Stroke and HC groups, PSD exhibited increased ALFF in the contralesional dorsolateral prefrontal cortex (DLPFC) and insula in all three frequency bands. Increased ALFF in ipsilesional DLPFC were observed in both slow-4 and classic frequency bands which were positively correlated with depression scales in PSD, while increased ALFF in the bilateral hippocampus and contralesional rolandic operculum were only found in slow-5 frequency band. These PSD-specific alterations in different frequency bands could predict depression severity. Moreover, decreased dALFF in contralesional superior temporal gyrus were observed in PSD group. LIMITATIONS: Longitudinal studies are required to explore the alterations of ALFF in PSD as the disease progress. CONCLUSIONS: The frequency-dependent and time-variant properties of ALFF could reflect the PSD-specific alterations in complementary ways, which may assist to elucidate underlying neural mechanisms and be helpful for early diagnosis and interventions for the disease. |
format | Online Article Text |
id | pubmed-10244813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102448132023-06-08 Frequency-dependent and time-variant alterations of neural activity in post-stroke depression: A resting-state fMRI study Wu, Xiumei Wang, Luoyu Jiang, Haibo Fu, Yanhui Wang, Tiantian Ma, Zhenqiang Wu, Xiaoyan Wang, Yiying Fan, Fengmei Song, Yulin Lv, Yating Neuroimage Clin Regular Article BACKGROUND: Post-stroke depression (PSD) is one of the most frequent psychiatric disorders after stroke. However, the underlying brain mechanism of PSD remains unclarified. Using the amplitude of low-frequency fluctuation (ALFF) approach, we aimed to investigate the abnormalities of neural activity in PSD patients, and further explored the frequency and time properties of ALFF changes in PSD. METHODS: Resting-state fMRI data and clinical data were collected from 39 PSD patients (PSD), 82 S patients without depression (Stroke), and 74 age- and sex-matched healthy controls (HC). ALFF across three frequency bands (ALFF-Classic: 0.01–0.08 Hz; ALFF-Slow4: 0.027–0.073 Hz; ALFF-Slow5: 0.01–0.027 Hz) and dynamic ALFF (dALFF) were computed and compared among three groups. Ridge regression analyses and spearman’s correlation analyses were further applied to explore the relationship between PSD-specific alterations and depression severity in PSD. RESULTS: We found that PSD-specific alterations of ALFF were frequency-dependent and time-variant. Specially, compared to both Stroke and HC groups, PSD exhibited increased ALFF in the contralesional dorsolateral prefrontal cortex (DLPFC) and insula in all three frequency bands. Increased ALFF in ipsilesional DLPFC were observed in both slow-4 and classic frequency bands which were positively correlated with depression scales in PSD, while increased ALFF in the bilateral hippocampus and contralesional rolandic operculum were only found in slow-5 frequency band. These PSD-specific alterations in different frequency bands could predict depression severity. Moreover, decreased dALFF in contralesional superior temporal gyrus were observed in PSD group. LIMITATIONS: Longitudinal studies are required to explore the alterations of ALFF in PSD as the disease progress. CONCLUSIONS: The frequency-dependent and time-variant properties of ALFF could reflect the PSD-specific alterations in complementary ways, which may assist to elucidate underlying neural mechanisms and be helpful for early diagnosis and interventions for the disease. Elsevier 2023-05-29 /pmc/articles/PMC10244813/ /pubmed/37269698 http://dx.doi.org/10.1016/j.nicl.2023.103445 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Wu, Xiumei Wang, Luoyu Jiang, Haibo Fu, Yanhui Wang, Tiantian Ma, Zhenqiang Wu, Xiaoyan Wang, Yiying Fan, Fengmei Song, Yulin Lv, Yating Frequency-dependent and time-variant alterations of neural activity in post-stroke depression: A resting-state fMRI study |
title | Frequency-dependent and time-variant alterations of neural activity in post-stroke depression: A resting-state fMRI study |
title_full | Frequency-dependent and time-variant alterations of neural activity in post-stroke depression: A resting-state fMRI study |
title_fullStr | Frequency-dependent and time-variant alterations of neural activity in post-stroke depression: A resting-state fMRI study |
title_full_unstemmed | Frequency-dependent and time-variant alterations of neural activity in post-stroke depression: A resting-state fMRI study |
title_short | Frequency-dependent and time-variant alterations of neural activity in post-stroke depression: A resting-state fMRI study |
title_sort | frequency-dependent and time-variant alterations of neural activity in post-stroke depression: a resting-state fmri study |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244813/ https://www.ncbi.nlm.nih.gov/pubmed/37269698 http://dx.doi.org/10.1016/j.nicl.2023.103445 |
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