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Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6

Dantrolene is a neutral hydantoin that is clinically used as a skeletal muscle relaxant to prevent overactivation of the skeletal muscle calcium release channel (RyR1) in response to volatile anesthetics. Dantrolene has aroused considerable recent interest as a lead compound for stabilizing calcium...

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Detalles Bibliográficos
Autores principales:	Walweel, Kafa, Beard, Nicole, van Helden, Dirk F., Laver, Derek R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244881/ https://www.ncbi.nlm.nih.gov/pubmed/37279522 http://dx.doi.org/10.1085/jgp.202213277

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