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Female infertility from oocyte maturation arrest: assembling the genetic puzzle
Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al identify infertile women bearing novel DNA sequence variants...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245026/ https://www.ncbi.nlm.nih.gov/pubmed/37073822 http://dx.doi.org/10.15252/emmm.202317729 |
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author | Ding, Xinbao Schimenti, John C |
author_facet | Ding, Xinbao Schimenti, John C |
author_sort | Ding, Xinbao |
collection | PubMed |
description | Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al identify infertile women bearing novel DNA sequence variants in a gene called PABPC1L, which is essential for translation of maternal mRNAs. By conducting a series of in vitro and in vivo experiments, they demonstrated certain variants as being causal for OMA, confirming a conserved requirement for PABPC1L in human oocyte maturation. This study offers a promising therapeutic target for treating OMA patients. |
format | Online Article Text |
id | pubmed-10245026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102450262023-06-08 Female infertility from oocyte maturation arrest: assembling the genetic puzzle Ding, Xinbao Schimenti, John C EMBO Mol Med News & Views Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al identify infertile women bearing novel DNA sequence variants in a gene called PABPC1L, which is essential for translation of maternal mRNAs. By conducting a series of in vitro and in vivo experiments, they demonstrated certain variants as being causal for OMA, confirming a conserved requirement for PABPC1L in human oocyte maturation. This study offers a promising therapeutic target for treating OMA patients. John Wiley and Sons Inc. 2023-04-19 /pmc/articles/PMC10245026/ /pubmed/37073822 http://dx.doi.org/10.15252/emmm.202317729 Text en © 2023 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | News & Views Ding, Xinbao Schimenti, John C Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
title | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
title_full | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
title_fullStr | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
title_full_unstemmed | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
title_short | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
title_sort | female infertility from oocyte maturation arrest: assembling the genetic puzzle |
topic | News & Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245026/ https://www.ncbi.nlm.nih.gov/pubmed/37073822 http://dx.doi.org/10.15252/emmm.202317729 |
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