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Female infertility from oocyte maturation arrest: assembling the genetic puzzle

Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al identify infertile women bearing novel DNA sequence variants...

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Detalles Bibliográficos
Autores principales: Ding, Xinbao, Schimenti, John C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245026/
https://www.ncbi.nlm.nih.gov/pubmed/37073822
http://dx.doi.org/10.15252/emmm.202317729
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author Ding, Xinbao
Schimenti, John C
author_facet Ding, Xinbao
Schimenti, John C
author_sort Ding, Xinbao
collection PubMed
description Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al identify infertile women bearing novel DNA sequence variants in a gene called PABPC1L, which is essential for translation of maternal mRNAs. By conducting a series of in vitro and in vivo experiments, they demonstrated certain variants as being causal for OMA, confirming a conserved requirement for PABPC1L in human oocyte maturation. This study offers a promising therapeutic target for treating OMA patients.
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spelling pubmed-102450262023-06-08 Female infertility from oocyte maturation arrest: assembling the genetic puzzle Ding, Xinbao Schimenti, John C EMBO Mol Med News & Views Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al identify infertile women bearing novel DNA sequence variants in a gene called PABPC1L, which is essential for translation of maternal mRNAs. By conducting a series of in vitro and in vivo experiments, they demonstrated certain variants as being causal for OMA, confirming a conserved requirement for PABPC1L in human oocyte maturation. This study offers a promising therapeutic target for treating OMA patients. John Wiley and Sons Inc. 2023-04-19 /pmc/articles/PMC10245026/ /pubmed/37073822 http://dx.doi.org/10.15252/emmm.202317729 Text en © 2023 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Ding, Xinbao
Schimenti, John C
Female infertility from oocyte maturation arrest: assembling the genetic puzzle
title Female infertility from oocyte maturation arrest: assembling the genetic puzzle
title_full Female infertility from oocyte maturation arrest: assembling the genetic puzzle
title_fullStr Female infertility from oocyte maturation arrest: assembling the genetic puzzle
title_full_unstemmed Female infertility from oocyte maturation arrest: assembling the genetic puzzle
title_short Female infertility from oocyte maturation arrest: assembling the genetic puzzle
title_sort female infertility from oocyte maturation arrest: assembling the genetic puzzle
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245026/
https://www.ncbi.nlm.nih.gov/pubmed/37073822
http://dx.doi.org/10.15252/emmm.202317729
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